Screening Potential Antitumor Agents from Natural Plant Extracts by G-Quadruplex Recognition and NMR Methods

Authors :: Junfeng Xiang
Lin Li
Yalin Tang
Qian Li
Qiuju Zhou
Qianfan Yang
Guangzhi Xu
Shu Yang
Hong Zhang
Source :: Angewandte Chemie. 120:5672-5674
Publication Year :: 2008
Publisher :: Wiley, 2008.
Abstract: mainlyfocusonscreeningmolecule(s)withknownstructure.However,uptonow,thescreeningofG-quadruplexligands from natural plant extracts, a complicated mixturesystem with multiform unknown chemical frames, has notbeenreported.Herein,weaddressanovelapproachforfastscreeningofG-quadruplex ligands from natural plant extracts. Thisapproach includes the following three steps: judging theexistence of G-quadruplex ligand(s) in the test extracts by

Subjects :: Magnetic Resonance Spectroscopy
Chemistry
Stereochemistry
Ligand
Plant Extracts
General Chemistry
Nuclear magnetic resonance spectroscopy
General Medicine
G-quadruplex
Antineoplastic Agents, Phytogenic
Catalysis
Molecular recognition
Biochemistry
Cell Line, Tumor
Humans
Drug Screening Assays, Antitumor
Chromatography, High Pressure Liquid

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