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Adjuvanted influenza vaccine for the Italian elderly in the 2018/19 season: an updated health technology assessment
- Source :
- The European Journal of Public Health
- Publication Year :
- 2019
-
Abstract
- Background The elderly, defined here as subjects aged ≥ 65 years, are among at-risk subjects for whom annual influenza vaccination is recommended. For the 2018/19 season, three vaccine types are available for the elderly in Italy: trivalent inactivated vaccine (TIV), adjuvanted TIV (aTIV) and quadrivalent inactivated vaccines (QIV). No health technology assessment (HTA) of seasonal influenza vaccination in the elderly has previously been conducted in Italy. Methods An HTA was conducted in 2017 to analyze the burden of influenza illness, the characteristics, efficacy, safety and cost-effectiveness of available vaccines and the related organizational and ethical implications. This was then contextualized to the 2018/19 influenza season. Comprehensive literature reviews/analyses were performed and a static mathematical model developed in order to address the above issues. Results In Italy, influenza is usually less common in the elderly than in other age-classes, but the burden of disease is the highest; >10% of infected elderly subjects develop complications, and about 90% of all influenza-related deaths occur in this age-class. All available vaccines are effective, safe and acceptable from an ethical standpoint. However, aTIV has proved more immunogenic and effective in the elderly. Furthermore, from the third payer’s perspective, aTIV is highly cost-effective and cost-saving in comparison with TIV and QIV, respectively. Nevertheless, vaccination coverage needs to be improved. Conclusions According to this HTA, aTIV appeared the vaccine of choice in the elderly. HTA should be reapplied whenever new relevant data become available.
- Subjects :
- medicine.medical_specialty
Technology Assessment, Biomedical
Influenza vaccine
Cost-Benefit Analysis
Adjuvanted, influenza, vaccine
Seasonal influenza
03 medical and health sciences
0302 clinical medicine
Adjuvants, Immunologic
Environmental health
Influenza, Human
Medicine
Humans
030212 general & internal medicine
Settore MED/42 - IGIENE GENERALE E APPLICATA
Migration
030304 developmental biology
Aged
0303 health sciences
business.industry
Public health
Public Health, Environmental and Occupational Health
Vaccino
Age Factors
Health technology
Health Technology Assessment
Influenza
Vaccination
Treatment Outcome
Immunization
Italy
Influenza Vaccines
Vaccination coverage
Inactivated vaccine
business
Vaccine
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- The European Journal of Public Health
- Accession number :
- edsair.doi.dedup.....cb0f772a096c85a24cb14d5139a81c5c