The role of cannabinoid receptor 2 in oligo/poly-articular juvenile idiopathic arthritis

Juvenile Idiopathic Arthritis(JIA) is an inflammatory chronic disease concerning joints and others structures. According to International League of Association for Rheumatology (ILAR) seven subtypes of arthritis can be defined in relation with the number of joints and the extra-articular involvement occurring in the first six months of disease. Although JIA pathogenesis is not completely clear is known that T-cell activation is a feature of oligoarticular and polyarticular JIA. The endocannabinoid system is involved in immune regulation by reducing cells activation, modulating Th1 and Th2 balance, inhibiting proinflammatory cytokine production. T-cell and other cellular components of immune system express cannabinoid receptor 1 and 2 (CB1-CB2).