Back to Search
Start Over
Design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3 study)
- Source :
- Contemporary Clinical Trials Communications, Vol 15, Iss, Pp-(2019), Contemporary Clinical Trials Communications
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Intake of nutrients fundamental for optimal neuronal function is of increasing interest. The potential importance of omega-3 highly unsaturated fatty acids (HUFAs) for optimizing emotional states, cognitive function, and mental health has been demonstrated in observational studies and randomized controlled trials. Omega-3 (HUFAs), specifically EPA (eicosapentaenoic acid) and docosahexaenoic acid (DHA), are concentrated in neural tissues and are essential for neural function, normative neurodevelopment, neurotransmitter, and neural immune functions. Omega-3 HUFAs must be obtained from the diet, predominantly from marine sources such as fish and other seafood. HUFAs also can be found in a variety of dietary supplements (omega-3 fatty acid esters, fish oil and krill oil). As dietary supplements, omega-3 HUFAs (fatty acid esters, fish and krill oils) differ substantially in their physicochemical properties and nutrient content. Here we present the design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3) study. RRIPP-3 was a double blind, randomized, controlled trial among individuals in the United States (US) Army Infantry Basic Officer Leaders Course (IBOLC) and following US Ranger School training (RC) at Fort Benning, GA of omega-3 HUFA on krill oil versus placebo supplementation. The RRIPP-3 study sought to determine if krill oil supplementation with omega-3 HUFAs supports aspects of cognitive functioning critical to battlefield success when measured immediately after an intense combat simulation. Sub-analyses addressed basic improvements in IBOLC performance. We also describe additional outcome measures critical for interpretation of the study results, such as diet and other dietary supplement use. Keywords: Omega-3 fatty acids, Cognition, Krill oil, US Army officers, Phospholipids, Resilience
- Subjects :
- Krill
Phospholipid
Krill oil
Article
US Army officers
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Nutrient
Cognition
Omega-3 fatty acids
030212 general & internal medicine
Food science
Phospholipids
Pharmacology
chemistry.chemical_classification
lcsh:R5-920
biology
Resilience
Fatty acid
General Medicine
biology.organism_classification
Fish oil
Eicosapentaenoic acid
chemistry
Docosahexaenoic acid
lcsh:Medicine (General)
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 24518654
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Contemporary Clinical Trials Communications
- Accession number :
- edsair.doi.dedup.....cb07057410991444b1506c7eb04d43c7