Relationship between metformin use, vitamin B12 deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes

Authors :: Keishi Yamauchi
Toru Aizawa
Yuka Sato
Kenjiro Ouchi
Yoshiko Funase
Source :: Endocrine Journal. 60:1275-1280
Publication Year :: 2013
Publisher :: Japan Endocrine Society, 2013.
Abstract: Aim of the study was to clarify the relationship between metformin-induced vitamin B12 (B12) deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes. Serum B12 concentrations, homocysteine plasma levels, the presence of retinopathy and history of macroangiopathy (stroke or coronary heart disease) were analyzed in patients without renal dysfunction (serum creatinine

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