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HNF1α controls renal glucose reabsorption in mouse and man
- Source :
- EMBO Reports, EMBO Reports, EMBO Press, 2000, 1 (4), pp.359-65. ⟨10.1093/embo-reports/kvd071⟩, EMBO Reports, 2000, 1 (4), pp.359-65. ⟨10.1093/embo-reports/kvd071⟩, Scopus-Elsevier
- Publication Year :
- 2000
- Publisher :
- EMBO, 2000.
-
Abstract
- Recently it has been shown that dominant mutations in the human hepatocyte nuclear factor 1alpha (HNF1alpha) gene, encoding for a homeoprotein that is expressed in liver, kidney, pancreas and intestine, result in maturity onset diabetes of the young type 3 (MODY3). HNF1alpha-null mice are diabetic, but at the same time suffer from a renal Fanconi syndrome characterized by urinary glucose loss. Here we show that MODY3 patients are also characterized by a reduced tubular reabsorption of glucose. The renal murine defect is due to reduced expression of the low affinity/high capacity glucose cotransporter (SGLT2). Our results show that HNF1alpha directly controls SGLT2 gene expression. Together these data indicate that HNF1alpha plays a key role in glucose homeostasis in mammals.
- Subjects :
- Blood Glucose
Male
MESH: Mice, Knockout
Biochemistry
Kidney Tubules, Proximal
Mice
0302 clinical medicine
MESH: Reverse Transcriptase Polymerase Chain Reaction
Glucose homeostasis
MESH: Animals
Hepatocyte Nuclear Factor 1-alpha
Luciferases
Promoter Regions, Genetic
Mice, Knockout
Genomic Library
0303 health sciences
Kidney
MESH: Middle Aged
Reverse Transcriptase Polymerase Chain Reaction
MESH: Hepatocyte Nuclear Factor 1
Nuclear Proteins
MESH: Genomic Library
MESH: Transcription Factors
Middle Aged
3. Good health
Renal glucose reabsorption
DNA-Binding Proteins
MESH: Glucose
MESH: Promoter Regions (Genetics)
medicine.anatomical_structure
MESH: Sodium-Glucose Transporter 2
MESH: Monosaccharide Transport Proteins
Hepatocyte Nuclear Factor 1
Female
MESH: Diabetes Mellitus, Type 1
Adult
MESH: DNA Primers
endocrine system
medicine.medical_specialty
MESH: Mutation
Monosaccharide Transport Proteins
MESH: Biological Transport
030209 endocrinology & metabolism
Carbohydrate metabolism
Biology
Transfection
Maturity onset diabetes of the young
Absorption
03 medical and health sciences
Sodium-Glucose Transporter 2
MESH: Kidney Tubules, Proximal
Internal medicine
Diabetes mellitus
Genetics
medicine
Animals
Humans
MESH: Blotting, Northern
MESH: Hepatocyte Nuclear Factor 1-beta
MESH: Hepatocyte Nuclear Factor 1-alpha
MESH: Mice
Molecular Biology
DNA Primers
Hepatocyte Nuclear Factor 1-beta
030304 developmental biology
MESH: Humans
MESH: Transfection
Scientific Reports
MESH: Absorption
Biological Transport
MESH: Adult
Blotting, Northern
medicine.disease
Molecular biology
MESH: Male
Diabetes Mellitus, Type 1
Glucose
Endocrinology
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
Renal physiology
Mutation
MESH: Blood Glucose
Hepatocyte Nuclear Factor 1-Beta
MESH: Luciferases
MESH: Nuclear Proteins
MESH: Female
MESH: DNA-Binding Proteins
Transcription Factors
Subjects
Details
- ISSN :
- 14693178 and 1469221X
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- EMBO reports
- Accession number :
- edsair.doi.dedup.....caf192c061051ef40af1ecd3ee49a9a1