Back to Search
Start Over
Advances in the diagnosis and treatment of Clostridium difficile infections
- Source :
- Emerging Microbes & Infections
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- Clostridium difficile is a leading cause of antibiotic-associated diarrhea worldwide. The diagnosis of C. difficile infection (CDI) requires both clinical manifestations and a positive laboratory test for C. difficile and/or its toxins. While antibiotic therapy is the treatment of choice for CDI, there are relatively few classes of effective antibiotics currently available. Therefore, the development of novel antibiotics and/or alternative treatment strategies for CDI has received a great deal of attention in recent years. A number of emerging agents such as cadazolid, surotomycin, ridinilazole, and bezlotoxumab have demonstrated activity against C. difficile; some of these have been approved for limited clinical use and some are in clinical trials. In addition, other approaches such as early and accurate diagnosis of CDI as well as disease prevention are important for clinical management. While the toxigenic culture and the cell cytotoxicity neutralization assay are still recognized as the gold standard for the diagnosis of CDI, new diagnostic approaches such as nucleic acid amplification methods have become available. In this review, we will discuss both current and emerging diagnostic and therapeutic modalities for CDI.
- Subjects :
- Diarrhea
0301 basic medicine
medicine.medical_specialty
genetic structures
Epidemiology
medicine.drug_class
030106 microbiology
Immunology
Antibiotics
Surotomycin
Review Article
Microbiology
03 medical and health sciences
chemistry.chemical_compound
Virology
Drug Discovery
Animals
Humans
Medicine
Intensive care medicine
Clostridioides difficile
business.industry
General Medicine
Gold standard (test)
Clostridium difficile
Anti-Bacterial Agents
Clinical trial
Infectious Diseases
Bezlotoxumab
chemistry
Clostridium Infections
Parasitology
medicine.symptom
business
Cadazolid
Subjects
Details
- ISSN :
- 22221751
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Emerging Microbes & Infections
- Accession number :
- edsair.doi.dedup.....caf07ce10121ec10306e725acce2418a