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Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y)
- Source :
- Neuroscience letters. 593
- Publication Year :
- 2014
-
Abstract
- Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates proliferation, cell migration, survival and differentiation by specific receptors activation. We studied its effects on L-BMAA treated neuroblastoma cells (SH-SY5Y), an amino acid that can trigger neurodegenerative diseases such as amyotrophic lateral sclerosis/Parkinson dementia complex (ALS/PDC). We found that S1P protects from necrosis and prevents the GSK3 increasing as long as the PI3K/AKT pathway is active. Moreover, GSK3 inhibition protects against neuronal death caused by L-BMAA.
- Subjects :
- Necrosis
SH-SY5Y
Apoptosis
macromolecular substances
Biology
Neuroprotection
chemistry.chemical_compound
Glycogen Synthase Kinase 3
Phosphatidylinositol 3-Kinases
Sphingosine
Cell Line, Tumor
medicine
Humans
Sphingosine-1-phosphate
Receptor
PI3K/AKT/mTOR pathway
chemistry.chemical_classification
Neurons
Cyanobacteria Toxins
General Neuroscience
Amino Acids, Diamino
Cell migration
Amino acid
Neuroprotective Agents
chemistry
Biochemistry
Cancer research
medicine.symptom
Lysophospholipids
Proto-Oncogene Proteins c-akt
Signal Transduction
Subjects
Details
- ISSN :
- 18727972
- Volume :
- 593
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....caebf85f163c768eb72e175cbbe561f9