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Mechanisms of RNA loading into exosomes
- Source :
- FEBS Letters. 589(13):1391-1398
- Publication Year :
- 2015
-
Abstract
- Upon fusion of multivesicular bodies (MVBs) with the plasma membrane, intraluminal vesicles (ILVs) are released into the extracellular space as exosomes. Since the lipid composition of the exosomal membrane resembles that of raft microdomains, the inward budding process involves the raft-like region of the MVB limiting membrane. Although published research suggests that cellular RNAs may be selectively sorted into exosomes, the molecular mechanisms remain elusive. In this review, we suggest that there is a continuous interaction of cellular RNAs with the outer (cytoplasmic) surface of MVBs and that the selection for incorporation of these RNAs into ILVs is based on their affinity to the raft-like region in the outer layer of the MVB membrane.
- Subjects :
- Ceramide
Biophysics
Biology
Exosomes
Models, Biological
Biochemistry
Intraluminal vesicles
Membrane Lipids
chemistry.chemical_compound
Rafts
Membrane Microdomains
Structural Biology
microRNA
Genetics
Extracellular
Animals
Humans
Molecular Biology
Vesicle
Cell Membrane
Membrane
Multivesicular Bodies
RNA-Binding Proteins
RNA
MicroRNA
Cell Biology
Raft
Microvesicles
Cell biology
chemistry
Cytoplasm
lipids (amino acids, peptides, and proteins)
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 589
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....caeb18014689341672d41ed4f4a149ea