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The synovitis of 'non-inflammatory' orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis
- Source :
- Annals of the Rheumatic Diseases. 67:1184-1187
- Publication Year :
- 2008
- Publisher :
- BMJ, 2008.
-
Abstract
- To quantify inflammatory changes in synovial membranes from orthopaedic "non-inflammatory" arthropathies (Orth. A).Synovial membranes from patients with femur fracture, avascular necrosis of the femur, plica syndrome, and meniscus and/or ligament injury (n = 23); rheumatoid arthritis (n = 28); osteoarthritis (OA; n = 25); and from normal controls (n = 10) were assessed by light microscopy, a histological synovitis score, immunostaining for CD3, CD20, CD38, CD68, Ki-67 and von Willebrand factor, and with an immunohistochemical inflammation score.Orth. A histology varied between normal and markedly inflamed. Predominant abnormalities were mild lining hyperplasia, scattered inflammatory cells and small perivascular infiltrates. The synovitis score classified Orth. A as "mild synovitis". Inflammatory cells occurred frequently: CD68+ cells in 100% of Orth. A specimens; CD3+, 91%; CD38+, 70%; and CD20+, 39%. Orth. A had 36% greater lining thickness (p = 0.04), 40% higher vascular density (p = 0.009) and 51.3-fold higher CD38+ cell density (p = 0.02) than normal controls; and 60% fewer subintimal Ki-67+ cells (p = 0.003), 42% fewer CD68+ lining cells (p0.01) and 40% fewer subintimal CD68+ cells (p0.01) than OA. The immunohistochemical inflammation score was 2.2-fold higher in Orth. A than in controls (p = 0.048) and similar to OA, with three Orth. A specimens showing marked inflammation.Synovial membranes from "non-inflammatory" arthropathies featured neovascularisation and inflammation intermediate between normal and OA synovium. These results expand previous findings that mechanical joint injury may lead to a mild-to-moderate synovitis.
- Subjects :
- Pathology
medicine.medical_specialty
CD3 Complex
Immunology
Antigens, Differentiation, Myelomonocytic
Arthritis
Osteoarthritis
Statistics, Nonparametric
General Biochemistry, Genetics and Molecular Biology
Arthritis, Rheumatoid
Necrosis
Rheumatology
Antigens, CD
Synovitis
von Willebrand Factor
medicine
Humans
Immunology and Allergy
Femur
Plica syndrome
Femur fracture
Ligaments
business.industry
Synovial Membrane
Hyperplasia
Antigens, CD20
medicine.disease
ADP-ribosyl Cyclase 1
Immunohistochemistry
medicine.anatomical_structure
Case-Control Studies
Rheumatoid arthritis
Joints
Synovial membrane
business
Femoral Fractures
Biomarkers
Subjects
Details
- ISSN :
- 00034967
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Annals of the Rheumatic Diseases
- Accession number :
- edsair.doi.dedup.....cae1f5e65270c2e4064b1131eb259d4c