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‘Plantibodies’: a flexible approach to design resistance against pathogens
- Source :
- Netherlands Journal of Plant Pathology 98 (1992) suppl.2, Netherlands Journal of Plant Pathology, 98(suppl.2), 183-191
- Publication Year :
- 1992
- Publisher :
- Springer Science and Business Media LLC, 1992.
-
Abstract
- Engineering resistance against various diseases and pests is hampered by the lack of suitable genes. To overcome this problem we started a research program aimed at obtaining resistance by transfecting plants with genes encoding monoclonal antibodies against pathogen specific proteins. The idea is that monoclonal antibodies will inhibit the biological activity of molecules that are essential for the pathogenesis. Potato cyst nematodes are chosen as a model and it is thought that monoclonal antibodies are able to block the function of the saliva proteins of this parasite. These proteins are, among others, responsible for the induction of multinucleate transfer cells upon which the nematode feeds. It is well documented that the ability of antibodies to bind molecules is sufficient to inactivate the function of an antigen and in view of the potential of animals to synthesize antibodies to almost any molecular structure, this strategy should be feasible for a wide range of diseases and pests.
- Subjects :
- biology
medicine.drug_class
Plant Science
Horticulture
Monoclonal antibody
scFv
single chain antibodies
Microbiology
Antigen
Immunology
biology.protein
medicine
Plantibody
Monoclonal antibodies
Laboratory of Nematology
Antibody
potato cyst nematodes
Laboratorium voor Nematologie
Agronomy and Crop Science
Gene
Pathogen
Function (biology)
Single-Chain Antibodies
Subjects
Details
- ISSN :
- 15738469 and 00282944
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Netherlands Journal of Plant Pathology
- Accession number :
- edsair.doi.dedup.....cad49057d10575010014cbe03ce93501