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Modification of Apremilast from Pills to Aerosol a Future Concept
- Source :
- International Journal of Environmental Research and Public Health, Vol 18, Iss 11590, p 11590 (2021), International Journal of Environmental Research and Public Health
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Background: Inhaled drugs have been available in the market for several years and for several diseases. Drugs for chronic obstructive pulmonary disease, cystic fibrosis, and diabetes have been used for several years. In the field of drug modification, these drugs range from tablets to aerosol. Methods: Milling as used to break down the tablets to powder and nebulisers are used to produce aerosol droplets. A mastersizer was used to measure the mass median aerodynamic diameter of the aerosol droplets. Results: Apremilast produced mmad diameters (2.43 μm) without any statistical difference between the different jet-nebulizers. The residual cup B contributed to greater mmad diameters as the 95% interval of mean values, based on those the ANOVA mean square clearly indicated, followed by cups C and F. The previous interval plot is much better clarified when the interaction means between drug and residual cap are plotted. The residual cups B, C and F produce mmad between (2.0–3.2). Conclusion: In the current research study we demonstrated our methodology to create apremilast powder and produce apremilast aerosol droplets with different nebulisers and residual cups.
- Subjects :
- Mean square
Materials science
Health, Toxicology and Mutagenesis
Statistical difference
Pulmonary disease
apremilast
complex mixtures
Pulmonary Disease, Chronic Obstructive
mastersizer
Administration, Inhalation
medicine
Humans
Aerodynamic diameter
jet-nebulisers
ddc:610
Particle Size
nebulisers
Aerosols
ultrasound nebulisers
Nebulizers and Vaporizers
Brief Report
Public Health, Environmental and Occupational Health
psoriasis
Thalidomide
Aerosol
Medicine
Apremilast
Biomedical engineering
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 16617827 and 16604601
- Volume :
- 18
- Issue :
- 11590
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....caca85daac6f4a2c3c60e9bb317bc4d4