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Trends and Exceptions in the Interaction of Hydroxamic Acid Derivatives of Common Di- and Tripeptides with Some 3d and 4d Metal Ions in Aqueous Solution
- Source :
- Molecules, Vol 24, Iss 21, p 3941 (2019), Molecules, Volume 24, Issue 21, Molecules (Basel, Online) 24 (2019). doi:10.3390/molecules24213941, info:cnr-pdr/source/autori:Ozsvath A.; Biro L.; Nagy E.M.; Buglyo P.; Sanna D.; Farkas E./titolo:Trends and exceptions in the interaction of hydroxamic acid derivatives of common di-and tripeptides with some 3d and 4d metal ions in aqueous solution/doi:10.3390%2Fmolecules24213941/rivista:Molecules (Basel, Online)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:24
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- By using various techniques (pH-potentiometry, UV-Visible spectrophotometry, 1H and 17O-NMR, EPR, ESI-MS), first time in the literature, solution equilibrium study has been performed on complexes of dipeptide and tripeptide hydroxamic acids&mdash<br />AlaAlaNHOH, AlaAlaN(Me)OH, AlaGlyGlyNHOH, and AlaGlyGlyN(Me)OH&mdash<br />with 4d metals: the essential Mo(VI) and two half-sandwich type cations, [(&eta<br />6-p-cym)Ru(H2O)3]2+ as well as [(&eta<br />5-Cp*)Rh(H2O)3]2+, the latter two having potential importance in cancer therapy. The tripeptide derivatives have also been studied with some biologically important 3d metals, such as Fe(III), Ni(II), Cu(II), and Zn(II), in order to compare these new results with the corresponding previously obtained ones on dipeptide hydroxamic acids. Based on the outcomes, the effects of the type of metal ions, the coordination number, the number and types of donor atoms, and their relative positions to each other on the complexation have been evaluated in the present work. We hope that these collected results might be used when a new peptide-based hydroxamic acid molecule is planned with some purpose, e.g. to develop a potential metalloenzyme inhibitor.
- Subjects :
- Models, Molecular
metal complexation
Proton Magnetic Resonance Spectroscopy
Coordination number
Metal ions in aqueous solution
Pharmaceutical Science
Peptide
Tripeptide
peptide hydroxamic acids
Hydroxamic Acids
Ligands
Medicinal chemistry
Article
Analytical Chemistry
law.invention
lcsh:QD241-441
chemistry.chemical_compound
lcsh:Organic chemistry
law
Drug Discovery
Molecule
Physical and Theoretical Chemistry
Electron paramagnetic resonance
Ions
chemistry.chemical_classification
Dipeptide
Hydroxamic acid
Organic Chemistry
solution equilibrium
Water
Hydrogen-Ion Concentration
Solutions
chemistry
Metals
Chemistry (miscellaneous)
Molecular Medicine
Spectrophotometry, Ultraviolet
mo(vi) complexes
Protons
Peptides
ru(ii)-, rh(iii)-based half-sandwich complexes
Ru(II)- Rh(III)-based half-sandwich complexes
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 24
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....caa840c1b21d0cfd7724e0aa7b9401fb