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Exacerbations of Severe Asthma While on Anti–IL-5 Biologics
- Source :
- Journal of Investigational Allergology and Clinical Immunology. 30:307-316
- Publication Year :
- 2020
- Publisher :
- Esmon Publicidad, SA, 2020.
-
Abstract
- Anti-interleukin 5 (IL-5) and anti-IL-5 receptor α monoclonal antibodies markedly decrease airway and peripheral blood eosinophil numbers and are thus highly effective in reducing asthma exacerbations. Nonetheless, these biologics do not completely resolve exacerbations. There is very little information on the cellular nature of exacerbations during treatment with biologics. Using illustrative clinical case scenarios, we highlight the importance of carefully characterizing asthmatics at the time of exacerbation and recognizing neutrophilic causes of exacerbations to ensure optimal management. While an eosinophilic exacerbation may improve with more corticosteroids or by switching to another anti-IL-5 monoclonal antibody, a noneosinophilic exacerbation will likely not. An infective exacerbation needs to be recognized, and the pathogen must be identified and treated with the appropriate antimicrobial agent.
- Subjects :
- Male
0301 basic medicine
Exacerbation
medicine.drug_class
Severe asthma
Immunology
Antibodies, Monoclonal, Humanized
Monoclonal antibody
Leukocyte Count
03 medical and health sciences
0302 clinical medicine
Eosinophilic
medicine
Animals
Humans
Immunology and Allergy
Anti-Asthmatic Agents
030223 otorhinolaryngology
Aged
Aged, 80 and over
business.industry
Sputum
Antibodies, Monoclonal
Disease Management
Middle Aged
Eosinophil
Receptors, Interleukin-5
Asthma
Optimal management
Respiratory Function Tests
Eosinophils
Anti il 5
Treatment Outcome
030104 developmental biology
medicine.anatomical_structure
Disease Progression
Female
Interleukin-5
Tomography, X-Ray Computed
Airway
business
Subjects
Details
- ISSN :
- 10189068
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Journal of Investigational Allergology and Clinical Immunology
- Accession number :
- edsair.doi.dedup.....ca998acce0f4b21cdb9a671302a18b68