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The CIRCuiTS study (Implementation of cognitive remediation in early intervention services): protocol for a randomised controlled trial
- Source :
- Trials, Vol 19, Iss 1, Pp 1-12 (2018), Trials
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Background Cognitive problems in people with schizophrenia predict poor functional recovery even with the best possible rehabilitation opportunities and optimal medication. A psychological treatment known as cognitive remediation therapy (CRT) aims to improve cognition in neuropsychiatric disorders, with the ultimate goal of improving functional recovery. Studies suggest that intervening early in the course of the disorder will have the most benefit, so this study will be based in early intervention services, which treat individuals in the first few years following the onset of the disorder. The overall aim is to investigate different methods of CRT. Methods This is a multicentre, randomised, single-blinded, controlled trial based in early intervention services in National Health Service Mental Health Trusts in six English research sites. Three different methods of providing CRT (intensive, group, and independent) will be compared with treatment as usual. We will recruit 720 service users aged between 16 and 45 over 3 years who have a research diagnosis of non-affective psychosis and will be at least 3 months from the onset of the first episode of psychosis. The primary outcome measure will be the degree to which participants have achieved their stated goals using the Goal Attainment Scale. Secondary outcome measures will include improvements in cognitive function, social function, self-esteem, and clinical symptoms. Discussion It has already been established that cognitive remediation improves cognitive function in people with schizophrenia. Successful implementation in mental health services has the potential to change the recovery trajectory of individuals with schizophrenia-spectrum disorders. However, the best mode of implementation, in terms of efficacy, service user and team preference, and cost-effectiveness is still unclear. The CIRCuiTS trial will provide guidance for a large-scale roll-out of CRT to mental health services where cognitive difficulties impact recovery and resilience. Trial registration ISRCTN, ISRCTN14678860, Registered on 6 June 2016. Electronic supplementary material The online version of this article (10.1186/s13063-018-2553-3) contains supplementary material, which is available to authorized users.
- Subjects :
- Adult
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Cost-Benefit Analysis
Medicine (miscellaneous)
law.invention
03 medical and health sciences
Study Protocol
Young Adult
0302 clinical medicine
Cognition
Randomized controlled trial
law
Recovery
Outcome Assessment, Health Care
Medicine
Humans
Multicenter Studies as Topic
Pharmacology (medical)
Single-Blind Method
Functioning
Psychiatry
Randomized Controlled Trials as Topic
First episode
lcsh:R5-920
Rehabilitation
business.industry
Middle Aged
medicine.disease
Mental health
Cognitive training
030227 psychiatry
Cognitive remediation therapy
Schizophrenia
Implementation
Early psychosis
Psychological therapy
Cognitive remediation
business
lcsh:Medicine (General)
030217 neurology & neurosurgery
RC
Cognitive enhancement
Subjects
Details
- Language :
- English
- ISSN :
- 17456215
- Volume :
- 19
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Trials
- Accession number :
- edsair.doi.dedup.....ca8ebfdf792e0a6dfe6d446e84d8b652