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Multifunctional nanoparticle composites: progress in the use of soft and hard nanoparticles for drug delivery and imaging
- Source :
- Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. 9(6)
- Publication Year :
- 2016
-
Abstract
- With continued advancements in nanoparticle (NP) synthesis and in the interfacing of NPs with biological systems has come the exponential growth in the use of NPs for therapeutic drug delivery and imaging applications. In recent years, the advent of NP multifunctionality-the ability to perform multiple, disparate functions on a single NP platform-has garnered much excitement for the potential realization of highly functional NP-mediated drug delivery for use in the clinical setting. This Overview will survey the current state of the art (reports published within the last 5 years) of multifunctional NPs for therapeutic drug delivery, imaging or a combination thereof. We provide extensive examples of both soft (micelles, liposomes, polymeric NPs) and hard (noble metals, quantum dots, metal oxides) NP formulations that have been used for multimodal drug delivery and imaging. The criteria for inclusion, herein, is that there must be at least two therapeutic drug cargos or imaging agents or a combination of the two. We next offer an assessment of the cytotoxicity of therapeutic NP constructs in biological systems. We then conclude with a forward-looking perspective on how we expect this field to develop in the coming years. WIREs Nanomed Nanobiotechnol 2017, 9:e1466. doi: 10.1002/wnan.1466 For further resources related to this article, please visit the WIREs website.
- Subjects :
- Drug
Diagnostic Imaging
Materials science
Theranostic Nanomedicine
media_common.quotation_subject
Multifunctional nanoparticles
Biomedical Engineering
Medicine (miscellaneous)
Nanoparticle
Bioengineering
Nanotechnology
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
0104 chemical sciences
Drug Delivery Systems
Hardness
Drug delivery
Animals
Humans
Nanoparticles
0210 nano-technology
media_common
Subjects
Details
- ISSN :
- 19390041
- Volume :
- 9
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
- Accession number :
- edsair.doi.dedup.....ca86c43a9c743eb3a90caff687e71e3f