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Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study

Authors :
Brian Rector
Chad Steele
Wendy C. Moore
Elizabeth J. Ampleford
Annette T. Hastie
Michelle Marks
Eugene R. Bleecker
Deborah A. Meyers
Source :
Thorax
Publication Year :
2020
Publisher :
BMJ, 2020.

Abstract

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reportedly promotes, or conversely, resolves inflammation in asthma. In this study of TRAIL and cell receptors in sputum, bronchoalveolar lavage and biopsy from subjects in the Severe Asthma Research Program at Wake Forest, the high TRAIL group had significant increases in all leucocytes, and was associated with increased type 1, type 2 and type 17 cytokines, but not type 9 interleukin 9. Two variants at loci in the TRAIL gene were associated with higher sputum levels of TRAIL. Increased TRAIL decoy receptor R3/DcR1 was observed on sputum leucocytes compared with death receptor R1/DR4, suggesting reduced apoptosis and prolonged cellular inflammation.

Details

ISSN :
14683296 and 00406376
Volume :
75
Database :
OpenAIRE
Journal :
Thorax
Accession number :
edsair.doi.dedup.....ca81c9f74ec3beffafa5888a9fc1cf5e
Full Text :
https://doi.org/10.1136/thoraxjnl-2019-214496