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Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study
- Source :
- Thorax
- Publication Year :
- 2020
- Publisher :
- BMJ, 2020.
-
Abstract
- Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reportedly promotes, or conversely, resolves inflammation in asthma. In this study of TRAIL and cell receptors in sputum, bronchoalveolar lavage and biopsy from subjects in the Severe Asthma Research Program at Wake Forest, the high TRAIL group had significant increases in all leucocytes, and was associated with increased type 1, type 2 and type 17 cytokines, but not type 9 interleukin 9. Two variants at loci in the TRAIL gene were associated with higher sputum levels of TRAIL. Increased TRAIL decoy receptor R3/DcR1 was observed on sputum leucocytes compared with death receptor R1/DR4, suggesting reduced apoptosis and prolonged cellular inflammation.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
Necrosis
Biopsy
Vital Capacity
Bronchi
Inflammation
Respiratory Mucosa
Brief Communication
Polymorphism, Single Nucleotide
Severity of Illness Index
cytokine biology
TNF-Related Apoptosis-Inducing Ligand
Leukocyte Count
Young Adult
03 medical and health sciences
0302 clinical medicine
Forced Expiratory Volume
Leukocytes
medicine
Humans
asthma mechanisms
Interleukin 9
Receptor
030304 developmental biology
0303 health sciences
medicine.diagnostic_test
business.industry
Sputum
Middle Aged
Asthma
respiratory tract diseases
Tumor Necrosis Factor Decoy Receptors
Cross-Sectional Studies
Bronchoalveolar lavage
030228 respiratory system
Apoptosis
Immunology
Cytokines
Female
medicine.symptom
business
Bronchoalveolar Lavage Fluid
Subjects
Details
- ISSN :
- 14683296 and 00406376
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Thorax
- Accession number :
- edsair.doi.dedup.....ca81c9f74ec3beffafa5888a9fc1cf5e
- Full Text :
- https://doi.org/10.1136/thoraxjnl-2019-214496