Back to Search
Start Over
Anterior Uveitis Accompanies Joint Disease in a Murine Model Resembling Ankylosing Spondylitis
- Source :
- Ophthalmic Research. 40:189-192
- Publication Year :
- 2008
- Publisher :
- S. Karger AG, 2008.
-
Abstract
- Background: Uveitis is often associated with a systemic inflammatory disease such as ankylosing spondylitis. Our understanding of the eye’s susceptibility to immune-mediated uveitis as in the apparent absence of infection has been limited by a relative lack of experimental models. Here we sought to assess whether ocular inflammation occurs in a previously described murine model of proteoglycan-induced spondylitis, wherein mice develop progressive spondylitis, sacroiliitis and peripheral arthritis – features common to the clinical presentations of ankylosing spondylitis. Methods: Using intravital microscopy we examined the ocular inflammatory response after the onset of arthritis in mice that overexpressed the T cell receptor (TCR) specific for a dominant arthritogenic epitope of cartilage proteoglycan [TCR-Tg (transgenic) mice] or BALB/c controls. Results: Immunized TCR-Tg mice showed a significant increase in the number of rolling and adhering cells within the iris vasculature compared to adjuvant control mice. Cellular infiltration within the iris tissue, as assessed by intravital microscopy and histology, was also increased. Our initial temporal analysis has revealed that immunized TCR-Tg mice show a significant increase in intravascular inflammation by 2 weeks after immunization, but it diminishes at 4 weeks after immunization. Conclusions: Although these data are preliminary, this model has the potential to clarify the mechanisms accounting for the coexistence of eye and sacroiliac inflammation as occurs in patients with ankylosing spondylitis.
- Subjects :
- Pathology
medicine.medical_specialty
Anterior Chamber
T-Lymphocytes
Receptors, Antigen, T-Cell
Arthritis
Inflammation
Leukocyte Count
Mice
Cellular and Molecular Neuroscience
medicine
Animals
Spondylitis, Ankylosing
Spondylitis
Mice, Inbred BALB C
Ankylosing spondylitis
business.industry
Sacroiliitis
General Medicine
medicine.disease
Uveitis, Anterior
Sensory Systems
Cellular infiltration
Disease Models, Animal
Ophthalmology
Immunology
Disease Progression
Female
Immunization
medicine.symptom
business
Uveitis
Intravital microscopy
Follow-Up Studies
Subjects
Details
- ISSN :
- 14230259 and 00303747
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Ophthalmic Research
- Accession number :
- edsair.doi.dedup.....ca78d41a705517adbba9400764df8616