Back to Search
Start Over
α¯ Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier
- Source :
- Medicinal Chemistry. 12:48-53
- Publication Year :
- 2016
- Publisher :
- Bentham Science Publishers Ltd., 2016.
-
Abstract
- Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.
- Subjects :
- Male
Aminoisobutyric Acids
010402 general chemistry
Blood–brain barrier
01 natural sciences
Mice
chemistry.chemical_compound
Nuclear magnetic resonance
Bimane
In vivo
Drug Discovery
medicine
Animals
Moiety
Tissue Distribution
Fluorescent Dyes
010405 organic chemistry
Chemistry
Transporter
Penetration (firestop)
Bridged Bicyclo Compounds, Heterocyclic
Fluorescence
0104 chemical sciences
Aminoisobutyric acid
medicine.anatomical_structure
Microscopy, Fluorescence
nervous system
Blood-Brain Barrier
cardiovascular system
Azabicyclo Compounds
Subjects
Details
- ISSN :
- 15734064
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....ca6c8534c4a5091387c34cf50b01cee9