Back to Search
Start Over
Development of the malaria parasite in the skin of the mammalian host
- Source :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2010, 107 (43), pp.18640-18645. ⟨10.1073/pnas.1009346107⟩, Proceedings of the National Academy of Sciences, 107(43), 18640-18645, Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (43), pp.18640-18645. ⟨10.1073/pnas.1009346107⟩
- Publication Year :
- 2010
- Publisher :
- HAL CCSD, 2010.
-
Abstract
- The first step of Plasmodium development in vertebrates is the transformation of the sporozoite, the parasite stage injected by the mosquito in the skin, into merozoites, the stage that invades erythrocytes and initiates the disease. The current view is that, in mammals, this stage conversion occurs only inside hepatocytes. Here, we document the transformation of sporozoites of rodent-infecting Plasmodium into merozoites in the skin of mice. After mosquito bite, ∼50% of the parasites remain in the skin, and at 24 h ∼10% are developing in the epidermis and the dermis, as well as in the immunoprivileged hair follicles where they can survive for weeks. The parasite developmental pathway in skin cells, although frequently abortive, leads to the generation of merozoites that are infective to erythrocytes and are released via merosomes, as typically observed in the liver. Therefore, during malaria in rodents, the skin is not just the route to the liver but is also the final destination for many inoculated parasites, where they can differentiate into merozoites and possibly persist.
- Subjects :
- Plasmodium
Plasmodium berghei
MESH: Plasmodium yoelii/pathogenicity
Schizogony
Mice
0302 clinical medicine
MESH: Anopheles/parasitology
MESH: Hair Follicle/parasitology
MESH: Dermis/parasitology
Parasite hosting
MESH: Animals
Skin
0303 health sciences
Multidisciplinary
biology
integumentary system
MESH: Malaria/transmission
MESH: Merozoites/growth & development
Anopheles
Dermis
Biological Sciences
3. Good health
medicine.anatomical_structure
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Sporozoites
MESH: Skin/parasitology
MESH: Plasmodium berghei/pathogenicity
intravital imaging Plasmodium schizogony plasmodium-berghei vaccine development sporozoites liver hepatocyte falciparum infection mosquito protein blimp1
Hair Follicle
Plasmodium yoelii
MESH: Plasmodium berghei/genetics
Green Fluorescent Proteins
030231 tropical medicine
MESH: Host-Parasite Interactions
MESH: Mice, Hairless
Host-Parasite Interactions
03 medical and health sciences
MESH: Mice, Inbred C57BL
parasitic diseases
schizogony
medicine
Animals
MESH: Mice
MESH: Malaria/parasitology
030304 developmental biology
Mice, Hairless
Merozoites
MESH: Plasmodium berghei/growth & development
MESH: Green Fluorescent Proteins/genetics
MESH: Plasmodium yoelii/growth & development
medicine.disease
biology.organism_classification
MESH: Plasmodium yoelii/genetics
Virology
Malaria
Mice, Inbred C57BL
MESH: Epidermis/parasitology
MESH: Sporozoites/growth & development
intravital imaging
Epidermis
Subjects
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2010, 107 (43), pp.18640-18645. ⟨10.1073/pnas.1009346107⟩, Proceedings of the National Academy of Sciences, 107(43), 18640-18645, Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (43), pp.18640-18645. ⟨10.1073/pnas.1009346107⟩
- Accession number :
- edsair.doi.dedup.....ca637e5813998b94e9e3169e9dc34459