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Clinical usefulness of a long-term treatment with an antithyroid drug for psoriasis vulgaris
- Source :
- Scopus-Elsevier
- Publication Year :
- 2005
-
Abstract
- We have previously reported that an antithyroid thiourethylene, thiamazole, can bring about significant clinical improvement in patients with psoriasis vulgaris. Although the efficacy of antithyroid thiourethylenes had been reported earlier, few studies have evaluated the safety of its long-term use. In this study, we aimed to study whether or not long-term thiamazole administration is complicated by any adverse effects. Eight patients with psoriasis vulgaris were enrolled in this study after informed consent was obtained. Each patient was administered thiamazole orally at 30 mg/day for 12 weeks. Two patients achieved complete clearance of psoriatic lesions. Four patients showed a significant improvement, and two patients did not reach satisfactory improvement. Some adverse effects developed in five patients; serum TSH levels elevated above the normal range in three patients and fell below the normal range in one patient. However, serum free- T3 and free- T4 levels remained within normal ranges during the treatment in all patients, and none of the patients developed clinical hypothyroidism. This preliminary study suggests that thiamazole administration is an effective and relatively safe treatment for patients with psoriasis vulgaris.
- Subjects :
- Drug
Adult
Male
medicine.medical_specialty
Long term treatment
media_common.quotation_subject
Administration, Oral
Dermatology
Risk Assessment
Severity of Illness Index
Drug Administration Schedule
Antithyroid Agents
Serum free
Informed consent
Psoriasis
Internal medicine
medicine
Humans
In patient
Prospective Studies
Adverse effect
Normal range
media_common
Methimazole
Dose-Response Relationship, Drug
business.industry
General Medicine
Middle Aged
medicine.disease
Long-Term Care
Surgery
Treatment Outcome
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 03852407
- Volume :
- 31
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- The Journal of dermatology
- Accession number :
- edsair.doi.dedup.....ca5f5f513b5ddc3f277af4638090d46e