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Cadherin-related family member 3 gene impacts childhood asthma in Chinese children
- Source :
- Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and ImmunologyREFERENCES. 31(2)
- Publication Year :
- 2019
-
Abstract
- BACKGROUND A missense variant (rs6967330) of the gene encoding cadherin-related family member 3 (CDHR3) was associated with recurrent severe exacerbations in pre-schoolers. However, there were limited data on its relationship with pre-school lung function and school-age asthma. This study replicated the association between polymorphic markers at the region of CDHR3 around rs6967330 and wheezing phenotypes in two independent cohorts of Chinese children. METHODS Ten tagging SNPs located 10 kb around rs6967330 were selected by HaploView 5.0 based on 1000 Genomes database for Southern Han Chinese. Their associations with wheezing and lung function were examined in 1341 Chinese pre-school children, while those for asthma phenotypes were examined in an independent group of 2079 school-age children. Genotypic and haplotypic associations were analyzed by multivariate regression, and generalized multifactor dimensionality reduction was used to examine epistatic interactions for wheezing traits. RESULTS The mean (SD) age of pre-school cohort was 4.7 (1.0) years. Rs6967330 was associated with current wheeze (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.09-2.43) and its severity (OR 1.64, 95% CI 1.10-2.44) among pre-school children. This SNP was also associated with school-age asthma (OR 1.32, 95% CI 1.04-1.69). The minor allele of rs408223 was associated with lower FEV0.5 (β = -2.411, P = .004) and FEV0.5 /FVC (β = -1.292, P = .015). Lower spirometric indices were also associated with minor allele of rs140154310. GAC haplotype from rs4730125, rs6967330, and rs408223 was associated with pre-school current wheeze and school-age asthma. Epistatic interaction was found between unrelated CDHR3 SNPs for FEV0.5 among pre-schoolers. CONCLUSION CDHR3 is a candidate gene for early-life wheezing, school-age asthma, and lung function in Chinese children.
- Subjects :
- Male
medicine.medical_specialty
Candidate gene
China
Genotype
Haploview
Immunology
Cadherin Related Proteins
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Cohort Studies
03 medical and health sciences
FEV1/FVC ratio
0302 clinical medicine
Gene Frequency
Internal medicine
Wheeze
medicine
Immunology and Allergy
Humans
Genetic Predisposition to Disease
030212 general & internal medicine
Genetic Association Studies
Asthma
Respiratory Sounds
business.industry
Membrane Proteins
Odds ratio
medicine.disease
Cadherins
Respiratory Function Tests
Minor allele frequency
030228 respiratory system
Child, Preschool
Pediatrics, Perinatology and Child Health
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 13993038
- Volume :
- 31
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and ImmunologyREFERENCES
- Accession number :
- edsair.doi.dedup.....ca5ceb8b659cdc2c10047646a3ad93d2