Back to Search
Start Over
Anti-idiotypic antibody specific for an infectious bursal disease virus-neutralizing monoclonal antibody does not interfere with the virus infection
- Source :
- Archives of Virology. 147:2017-2023
- Publication Year :
- 2002
- Publisher :
- Springer Science and Business Media LLC, 2002.
-
Abstract
- Infectious bursal disease virus (IBDV) capsid protein, VP2, contains a hypervariable domain that is recognized by virus-neutralizing antibodies. The virus-neutralizing epitope is highly conformation-dependent and the domain is speculated to be involved in the virus-target cell interaction. In this study, a polyclonal anti-idiotypic antibody (anti-id) was generated by the sequential immunization of a rabbit with a virus-neutralizing monoclonal antibody GI-11 which recognizes the VP2 hypervariable domain. Although the anti-id, which mimics the conformational epitope in the VP2 hypervariable domain, was expected to inhibit the virus infection, the anti-id did not interfere with either the virus binding or the infection to the target cell.
- Subjects :
- medicine.drug_class
viruses
Antibodies, Viral
Monoclonal antibody
Infectious bursal disease virus
Epitope
Virus
Infectious bursal disease
Neutralization Tests
Virology
medicine
Animals
Viral Structural Proteins
biology
Antibodies, Monoclonal
General Medicine
biochemical phenomena, metabolism, and nutrition
Birnaviridae Infections
medicine.disease
Antibodies, Anti-Idiotypic
Hypervariable region
Capsid
biology.protein
Rabbits
Antibody
Conformational epitope
Subjects
Details
- ISSN :
- 14328798 and 03048608
- Volume :
- 147
- Database :
- OpenAIRE
- Journal :
- Archives of Virology
- Accession number :
- edsair.doi.dedup.....ca5bcbfc55f88ad624731d9b6cb85535