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Functional brain changes in early Parkinson's disease during motor response and motor inhibition
- Source :
- Neurobiology of Aging. 32:115-124
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Motor impairment represents the main clinical feature of Parkinson's disease (PD). Cognitive deficits are also frequently observed in patients with PD, with a prominent involvement of executive functions and visuo-spatial abilities. We used event-related functional MRI (fMRI) and a paradigm based on visual attention and motor inhibition (Go/NoGO-task) to investigate brain activations in 13 patients with early PD in comparison with 11 healthy controls. The two groups did not report behavioural differences in task performance. During motor inhibition (NoGO-effect), PD patients compared to controls showed an increased activation in the prefrontal cortex and in the basal ganglia. They also showed a reduced and less coherent hemodynamic response in the occipital cortex. These results indicate that specific cortico-subcortical functional changes, involving not only the fronto-striatal network but also the temporal-occipital cortex, are already present in patients with early PD and no clinical evidence of cognitive impairment. We discuss our findings in terms of compensatory mechanisms (fronto-striatal changes) and preclinical signs of visuo-perceptual deficits and visual hallucinations.
- Subjects :
- Male
Aging
Parkinson's disease
genetic structures
Decision Making
Neuropsychological Tests
Brain mapping
Degenerative disease
Cortex (anatomy)
Basal ganglia
Image Processing, Computer-Assisted
medicine
Humans
Prefrontal cortex
Aged
Brain Mapping
General Neuroscience
Brain
Parkinson Disease
Middle Aged
medicine.disease
Executive functions
Magnetic Resonance Imaging
Oxygen
Functional imaging
Inhibition, Psychological
medicine.anatomical_structure
Female
Neurology (clinical)
Geriatrics and Gerontology
Cognition Disorders
Psychology
Neuroscience
psychological phenomena and processes
Developmental Biology
Subjects
Details
- ISSN :
- 01974580
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Neurobiology of Aging
- Accession number :
- edsair.doi.dedup.....ca4a3f930573c2e3073a2176f56b3cd0