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Higher free serum cortisol is associated with worse survival in acute variceal bleeding because of cirrhosis
- Source :
- European Journal of Gastroenterology & Hepatology. 26:1125-1132
- Publication Year :
- 2014
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2014.
-
Abstract
- BACKGROUND AND AIMS Critical illness-related corticosteroid insufficiency has been reported in acute variceal bleeding (AVB). In cirrhosis, free serum cortisol (FC) is considered optimal to assess adrenal function. Salivary cortisol (SC) is considered a surrogate for FC. We evaluated FC and its prognostic role in AVB. METHODS Total serum cortisol, SC, cortisol-binding globulin, and FC (Coolens' formula) were evaluated in AVB (n=38) and in stable cirrhosis (CC) (n=31). A Cox proportional hazards model was evaluated for 6-week survival. RESULTS In AVB, the median FC and SC levels were higher with worse liver dysfunction [Child-Pugh (CP) A/B/C: 1.59/2.62/3.26 μg/dl, P=0.019; CPA/B/C: 0.48/0.897/1.81 μg/ml, P
- Subjects :
- Liver Cirrhosis
Male
Time Factors
Cirrhosis
Hydrocortisone
Severity of Illness Index
Gastroenterology
Liver Function Tests
Risk Factors
London
Prospective Studies
Prospective cohort study
Aged, 80 and over
Greece
biology
Liver Neoplasms
Area under the curve
Middle Aged
Prognosis
Up-Regulation
Area Under Curve
Hepatocellular carcinoma
Acute Disease
Corticosteroid
Female
Gastrointestinal Hemorrhage
Adult
medicine.medical_specialty
Carcinoma, Hepatocellular
Globulin
medicine.drug_class
Serum Albumin, Human
Esophageal and Gastric Varices
Predictive Value of Tests
Internal medicine
Severity of illness
medicine
Adrenal insufficiency
Humans
Serum Albumin
Aged
Proportional Hazards Models
Chi-Square Distribution
Hepatology
business.industry
medicine.disease
Surgery
Logistic Models
ROC Curve
Multivariate Analysis
Adrenal Cortex
biology.protein
Carrier Proteins
business
Biomarkers
Subjects
Details
- ISSN :
- 0954691X
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- European Journal of Gastroenterology & Hepatology
- Accession number :
- edsair.doi.dedup.....ca41fc687fdb1ef6950b75f1ba832a68