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TMED2/p24β1 is expressed in all gestational stages of human placentas and in choriocarcinoma cell lines
- Source :
- Placenta. 33(3)
- Publication Year :
- 2011
-
Abstract
- Members of the transmembrane emp24 domain (Tmed)/p24 family of proteins are required for transport of proteins between the endoplasmic reticulum and the Golgi. One member of this family, Tmed2/p24β1, is expressed during placental development in mice and its expression is required for normal development of the labyrinth layer. Although TMED2 is conserved in humans, little is known about its expression and function in human placenta. We examined TMED2 expression in human placenta between 5.5 and 40 weeks of gestation and showed that TMED2 is expressed in syncytiotrophoblast, cytotrophoblast, and stromal cells. We also found high levels of TMED2 expression in BeWo but not in JEG-3 choriocarcinoma cell line. We used the BeWo cell line to determine TMED2 subcellular localization in placental cells and show its co-localization with the endoplasmic reticulum Golgi intermediate compartment. Our findings show conservation of TMED2 expression in human placenta and suggest that this protein may also play a role during placental development in humans.
- Subjects :
- Stromal cell
Term Birth
Placenta
Vesicular Transport Proteins
Gestational Age
Biology
symbols.namesake
Syncytiotrophoblast
Pregnancy
Cell Line, Tumor
medicine
Humans
Choriocarcinoma
reproductive and urinary physiology
Regulation of gene expression
Cytotrophoblast
Endoplasmic reticulum
Obstetrics and Gynecology
Gene Expression Regulation, Developmental
Membrane Proteins
Anatomy
Golgi apparatus
Subcellular localization
Placentation
Cell biology
Gene Expression Regulation, Neoplastic
Pregnancy Trimester, First
medicine.anatomical_structure
Reproductive Medicine
embryonic structures
Uterine Neoplasms
symbols
Female
Developmental Biology
Subjects
Details
- ISSN :
- 15323102
- Volume :
- 33
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Placenta
- Accession number :
- edsair.doi.dedup.....ca3db7b127724518d3f6eecc94a789c7