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Palindromic base sequences and replication of eukaryote chromosome ends

Authors :
Thomas Cavalier-Smith
Source :
Nature. 250:467-470
Publication Year :
1974
Publisher :
Springer Science and Business Media LLC, 1974.

Abstract

A new theory is proposed to explain the synthesis of the 5′ ends of linear DNA molecules. It suggests that chromosome ends consist of palindromic base sequences. These can form self-complementary hairpin loops, which can be converted by DNA ligase, a specific endonuclease, and DNA polymerase, into completely replicated ends.

Details

ISSN :
14764687 and 00280836
Volume :
250
Database :
OpenAIRE
Journal :
Nature
Accession number :
edsair.doi.dedup.....ca37b156c141fc0c207f309b43c80f0a