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Palindromic base sequences and replication of eukaryote chromosome ends
- Source :
- Nature. 250:467-470
- Publication Year :
- 1974
- Publisher :
- Springer Science and Business Media LLC, 1974.
-
Abstract
- A new theory is proposed to explain the synthesis of the 5′ ends of linear DNA molecules. It suggests that chromosome ends consist of palindromic base sequences. These can form self-complementary hairpin loops, which can be converted by DNA ligase, a specific endonuclease, and DNA polymerase, into completely replicated ends.
- Subjects :
- DNA Replication
DNA polymerase
Models, Biological
Terminally redundant DNA
Chromosomes
Endonuclease
chemistry.chemical_compound
Sticky and blunt ends
Animals
Insertion
chemistry.chemical_classification
Genetics
DNA ligase
Multidisciplinary
Base Sequence
biology
fungi
DNA replication
food and beverages
DNA
Biological Evolution
Chromatin
Polynucleotide Ligases
chemistry
DNA Nucleotidyltransferases
biology.protein
Subjects
Details
- ISSN :
- 14764687 and 00280836
- Volume :
- 250
- Database :
- OpenAIRE
- Journal :
- Nature
- Accession number :
- edsair.doi.dedup.....ca37b156c141fc0c207f309b43c80f0a