Back to Search
Start Over
BCL6 alternative translocation breakpoint cluster region associated with follicular lymphoma grade 3B
- Source :
- GENES CHROMOSOMES & CANCER, 44(3), 301-304. Wiley
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- Translocations involving band 3q27, affecting the major breakpoint region (MBR) of BCL6, are common in diffuse large B-cell lymphomas (DLBCLs). Recent data suggest an alternative breakpoint cluster region (ABR) located between 245 and 285 kb 5' of BCL6, which might be associated with Follicular Lymphoma (FL). Ten DLBCLs and 9 FLs grade 3B with cytogenetic rearrangements at 3q27 were studied by fluorescence in situ hybridization (FISH) to discriminate between breakpoints at the ABR and MBR. Eight DLBCLs contained a breakpoint in the MBR, and 6 FL grade 3B (FL3B) cases contained a breakpoint in the ABR. No specific chromosomal partners could be identified in both groups. Previously published data have suggested that FL3B cases with 3q27 aberrations are closely related to the majority of DLBCLs of germinal center cell origin. However, our findings suggest that the mechanism of 3q27 rearrangement in FL3B cases is similar to the mechanism in follicular lymphomas grade 1,2, and 3A cases. (c) 2005 Wiley-Liss, Inc.
- Subjects :
- BTB/POZ DOMAIN
EXPRESSION
Cancer Research
Follicular lymphoma
PROTEIN
Translocation Breakpoint
FINGER ENCODING GENE
Biology
Translocation, Genetic
hemic and lymphatic diseases
Genetics
medicine
Humans
NON-HODGKINS-LYMPHOMA
B-cell lymphoma
COMMON
Lymphoma, Follicular
In Situ Hybridization, Fluorescence
Chromosomes, Human, Pair 14
medicine.diagnostic_test
3Q27
Breakpoint
breakpoint cluster region
B-CELL LYMPHOMA
Germinal center
BCL6
medicine.disease
Molecular biology
Chromosomes, Human, Pair 3
Lymphoma, Large B-Cell, Diffuse
Fluorescence in situ hybridization
Subjects
Details
- ISSN :
- 10982264 and 10452257
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Genes, Chromosomes and Cancer
- Accession number :
- edsair.doi.dedup.....ca27771ec2dc5e6076fcd81409931cf7