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Biomechanical factors in atherosclerosis: mechanisms and clinical implications
- Source :
- Eur Heart Journal, European Heart Journal, Vol. 35 (2014) pp. 3013-3020, European heart journal, European Heart Journal, 35(43), 3013-+. Oxford University Press
- Publication Year :
- 2014
-
Abstract
- Blood vessels are exposed to multiple mechanical forces that are exerted on the vessel wall (radial, circumferential and Longitudinal forces) or on the endothelial surface (shear stress). The stresses and strains experienced by arteries influence the initiation of atherosclerotic Lesions, which develop at regions of arteries that are exposed to complex blood flow. In addition, plaque progression and eventually plaque rupture is influenced by a complex interaction between biological and mechanical factors mechanical forces regulate the cellular and molecular composition of plaques and, conversely, the composition of plaques determines their ability to withstand mechanical load. A deeper understanding of these interactions is essential for designing new therapeutic strategies to prevent lesion development and promote plaque stabilization. Moreover, integrating clinical imaging techniques with finite element modelling techniques allows for detailed examination of local morphological and biomechanical characteristics of atherosclerotic lesions that may be of help in prediction of future events. In this ESC Position Paper on biomechanical factors in atherosclerosis, we summarize the current 'state of the art' on the interface between mechanical forces and atherosclerotic plaque biology and identify potential clinical applications and key questions for future research.
- Subjects :
- Pathology
medicine.medical_specialty
Endothelium
Apoptosis
Review
Vascular Remodeling
030204 cardiovascular system & hematology
ddc:616.07
Biomechanical Phenomena
03 medical and health sciences
0302 clinical medicine
Homeostasis
Humans
Medicine
Mechanotransduction
Cellular Senescence
Mechanical energy
Cell Proliferation
030304 developmental biology
ddc:616
0303 health sciences
Mechanical load
Rupture, Spontaneous
business.industry
Endothelial Cells
Arteries
Blood flow
Atherosclerosis
medicine.disease
Plaque, Atherosclerotic
medicine.anatomical_structure
Atheroma
Disease Progression
Endothelium, Vascular
Stress, Mechanical
Cardiology and Cardiovascular Medicine
business
Mechanoreceptors
Neuroscience
Cell aging
Biomarkers
Signal Transduction
Subjects
Details
- ISSN :
- 0195668X
- Volume :
- 35
- Issue :
- 43
- Database :
- OpenAIRE
- Journal :
- Eur Heart Journal
- Accession number :
- edsair.doi.dedup.....ca1cf65cfbe5fc1304a2784ff7601bfb
- Full Text :
- https://doi.org/10.1093/eurheartj/ehu353