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Breast neoplasms: T2* susceptibility-contrast, first-pass perfusion MR imaging
- Source :
- Radiology. 202(1)
- Publication Year :
- 1997
-
Abstract
- To evaluate the differentiation of benign from malignant breast tumors with T2*-weighted perfusion magnetic resonance (MR) imaging (blood volume imaging) versus that with dynamic T1-weighted contrast agent-enhanced MR imaging.Ten healthy adult volunteers and 18 adult patients with benign or malignant lesions underwent both conventional T1-weighted dynamic contrast-enhanced breast MR imaging and repetitive first-pass, single-section, dynamic T2*-weighted perfusion MR imaging. Images were obtained before, during, and after injection of 20 mL of gadopentetate dimeglumine; peak gadopentetate dimeglumine concentrations were calculated from the maximal signal intensity loss on T2*-weighted images.No perfusion effect was detectable in healthy breast parenchyma. A strong susceptibility-mediated signal intensity loss occurred in malignant breast tumors. No or only minor perfusion effects were seen in fibroadenomas, in spite of their rapid enhancement at T1-weighted dynamic imaging. Perfusion imaging was possible after conventional dynamic contrast-enhanced breast MR imaging.T2*-weighted perfusion imaging exploits the susceptibility-mediated signal intensity loss of a first-pass bolus of gadopentetate dimeglumine within the capillary bed. First-pass perfusion imaging of breast lesions is feasible. It is promising in the differentiation of benign from malignant, rapidly enhancing lesions.
- Subjects :
- Adult
Gadolinium DTPA
medicine.medical_specialty
media_common.quotation_subject
Mammary gland
Contrast Media
Blood volume
Perfusion scanning
Breast Neoplasms
Diagnosis, Differential
Breast Diseases
Meglumine
Carcinoma
Organometallic Compounds
Medicine
Contrast (vision)
Humans
Radiology, Nuclear Medicine and imaging
Breast
media_common
Aged
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
Middle Aged
Pentetic Acid
medicine.disease
Mr imaging
Magnetic Resonance Imaging
Drug Combinations
medicine.anatomical_structure
Female
Radiology
business
Nuclear medicine
Perfusion
Subjects
Details
- ISSN :
- 00338419
- Volume :
- 202
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Radiology
- Accession number :
- edsair.doi.dedup.....ca1cf22ce73fa26eea8fb55a59975ded