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Biofunctionalization of scaffold material with nano-scaled diamond particles physisorbed with angiogenic factors enhances vessel growth after implantation
- Source :
- Nanomedicine: Nanotechnology, Biology and Medicine. 12:823-833
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Biofunctionalized scaffold facilitates complete healing of large defects. Biological constraints are induction and ingrowth of vessels. Angiogenic growth factors such as vascular endothelial growth factor or angiopoietin-1 can be bound to nano-scaled diamond particles. Corresponding bioactivities need to be examined after biofunctionalization. We therefore determined the physisorptive capacity of distinctly manufactured, differently sized nDP and the corresponding activities of bound factors. The properties of biofunctionalized nDPs were investigated on cultivated human mesenchymal stem cells and on the developing chicken embryo chorio-allantoic membrane. Eventually porous bone substitution material was coated with nDP to generate an interface that allows biofactor physisorption. Angiopoietin-1 was applied shortly before scaffold implantation into an osseous defect in sheep calvaria. Biofunctionalized scaffolds exhibited significantly increased rates of angiogenesis already one month after implantation. Conclusively, nDP can be used to ease functionalization of synthetic biomaterials. From the Clinical Editor With the advances in nanotechnology, many nano-sized materials have been used in the biomedical field. This is also true for nano-diamond particles (nDP). In this article, the authors investigated the physical properties of functionalized nano-diamond particles in both in-vitro and in-vivo settings. The positive findings would help improve understanding of these nanomaterials in regenerative medicine.
- Subjects :
- Vascular Endothelial Growth Factor A
Scaffold
Materials science
Biocompatibility
Angiogenesis
Biomedical Engineering
Neovascularization, Physiologic
Pharmaceutical Science
Medicine (miscellaneous)
Bioengineering
Nanotechnology
Chick Embryo
02 engineering and technology
010402 general chemistry
01 natural sciences
Regenerative medicine
Nanomaterials
Coated Materials, Biocompatible
Tissue engineering
Angiopoietin-1
Animals
Humans
General Materials Science
Nanodiamond
Sheep
Tissue Engineering
Tissue Scaffolds
Mesenchymal Stem Cells
021001 nanoscience & nanotechnology
Nanostructures
0104 chemical sciences
Bone Substitutes
Molecular Medicine
Surface modification
Angiogenesis Inducing Agents
Adsorption
Diamond
0210 nano-technology
Subjects
Details
- ISSN :
- 15499634
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Nanomedicine: Nanotechnology, Biology and Medicine
- Accession number :
- edsair.doi.dedup.....ca11d3ceeba67446baaaa8fa4a644d55