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Prognostic Impact of TumorāInfiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma Patients
- Source :
- The Laryngoscope. 131
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Objectives/hypothesis Tumor-infiltrating lymphocytes (TILs) has been shown to be associated with the prognosis of many tumors, yet few studies have investigated their roles in laryngeal squamous cell carcinoma (LSCC). We aim to investigate the prognostic values of tumor-infiltrating CD3+ /CD4+ /CD8+ /Foxp3+ T-cells and neutrophils in LSCC patients that received total or partial laryngectomy. Study design Retrospective case series of LSCC patients who underwent total or partial laryngectomy from 2013 to 2014 at Eye, Ear, Nose, and Throat Hospital of Fudan University. Methods In our study, 41 tumor tissues from patients with LSCC were retrospectively assessed using immunohistochemistry for CD3+ /CD4+ /CD8+ /Foxp3+ T-cells and CD66b+ neutrophils. Overall survival (OS) and disease-free survival (DFS) were recorded using Kaplan-Meier methods. Results Generally, patients with high density of TILs (CD3, CD4, CD8) showed improved OS or DFS. Specifically, high density of CD3+ TILs were associated with better OS, yet poorer OS and DFS for CD66b+ neutrophils. Patients with an Immunoscore of 0-1 experienced the worst OS and DFS, compared with Immunoscore 2-4 (P = .0111 for OS, P = .0391 for DFS). In Cox proportional hazards analysis adjusted for N stage and T stage, only stroma CD66b+ neutrophils densities were able to predict OS, with odds ratios of 4.819 (95% confidence interval [CI] 1.149-20.206; P = .032*), and DFS 2.888 (95% CI 1.043-7.997; P = .041*). Conclusions The density of TILs and CD66b+ neutrophils may help predict the prognosis of patients with LSCC after surgery. Level of evidence 3 Laryngoscope, 131:E1249-E1255, 2021.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Laryngectomy
Gastroenterology
03 medical and health sciences
Lymphocytes, Tumor-Infiltrating
0302 clinical medicine
Internal medicine
Humans
Medicine
Laryngeal Neoplasms
Aged
Neoplasm Staging
Retrospective Studies
business.industry
Proportional hazards model
Tumor-infiltrating lymphocytes
FOXP3
Odds ratio
Middle Aged
Prognosis
Confidence interval
Survival Rate
030104 developmental biology
Neutrophil Infiltration
Otorhinolaryngology
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Immunohistochemistry
T-stage
Female
business
CD8
Subjects
Details
- ISSN :
- 15314995 and 0023852X
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- The Laryngoscope
- Accession number :
- edsair.doi.dedup.....ca06cdcad932c335760fbb359f535a57