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Polymorphism of the migration of double-stranded RNA genome segments of reovirus isolates from humans, cattle, and mice
- Source :
- Journal of Virology. 31:104-111
- Publication Year :
- 1979
- Publisher :
- American Society for Microbiology, 1979.
-
Abstract
- A series of 94 isolates of reovirus from humans, cattle, and mice, showed extensive variability in the patterns of migration of the ten double-stranded RNA genome segments. This variation was found in all three serotypes, and involved all ten genome segments, including the segment responsible for serological specificity. Although a single pattern was present among several samples isolated from individuals and collected at a single time and place, there were often multiple genetic variants of a single serotype present in a population. Samples isolated from widely different geographic origins or different mammalian hosts showed different patterns; samples from a single species from the same area over a period of time showed more limited variations. Among most isolates, the migration of the slowest S segment, the segment that encodes the hemagglutinin and is responsible for serological specificity in laboratory strains, was similar to reference strains for type 1 and type 3 isolates. However, the type 2 isolates showed considerable variation in this segment.
- Subjects :
- Serotype
Genes, Viral
Immunology
Population
Anal Canal
Reoviridae
Biology
Microbiology
Genome
Serology
Feces
Mice
Polymorphism (computer science)
Virology
Animals
Humans
education
Mammalian orthoreovirus 3
RNA, Double-Stranded
Genetics
education.field_of_study
Polymorphism, Genetic
RNA
Hemagglutinin
biology.organism_classification
Insect Science
Pharynx
RNA, Viral
Cattle
Electrophoresis, Polyacrylamide Gel
Research Article
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....c9e14d036b3945e9fa53cf707ab3d43e