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Targeting Immune-Related Biological Processes in Solid Tumors: We do Need Biomarkers
- Source :
- International Journal of Molecular Sciences, Vol 20, Iss 21, p 5452 (2019), International Journal of Molecular Sciences
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Immunotherapy has become the standard-of-care in many solid tumors. Despite the significant recent achievements in the diagnosis and treatment of cancer, several issues related to patients’ selection for immunotherapy remain unsolved. Multiple lines of evidence suggest that, in this setting, the vision of a single biomarker is somewhat naïve and imprecise, given that immunotherapy does not follow the rules that we have experienced in the past for targeted therapies. On the other hand, additional immune-related biomarkers that are reliable in real-life clinical practice remain to be identified. Recently, the immune-checkpoint blockade has been approved in the US irrespective of the tumor site of origin. Further histology-agnostic approvals, coupled with with tumor-specific companion diagnostics and guidelines, are expected in this field. In addition, immune-related biomarkers can also have a significant prognostic value. In this review, we provide an overview of the role of these biomarkers and their characterization in the management of lung cancer, melanoma, colorectal cancer, gastric cancer, head and neck cancer, renal cell carcinoma, urothelial cancers, and breast cancer.
- Subjects :
- 0301 basic medicine
Oncology
Lung Neoplasms
medicine.medical_treatment
Pembrolizumab
Review
B7-H1 Antigen
Avelumab
lcsh:Chemistry
immunoediting
0302 clinical medicine
Cancer immunotherapy
Neoplasms
CTLA-4 Antigen
lcsh:QH301-705.5
Spectroscopy
gastrointestinal tract cancer
General Medicine
Prognosis
Kidney Neoplasms
Computer Science Applications
urothelial cancer
030220 oncology & carcinogenesis
biomarker
immunotherapy
Nivolumab
medicine.drug
medicine.medical_specialty
renal cell carcinoma
Ipilimumab
Breast Neoplasms
Catalysis
Inorganic Chemistry
03 medical and health sciences
Breast cancer
breast cancer
Atezolizumab
Internal medicine
medicine
Biomarkers, Tumor
melanoma
Humans
cancer
Physical and Theoretical Chemistry
Molecular Biology
Carcinoma, Renal Cell
business.industry
Organic Chemistry
Cancer
biomarkers
medicine.disease
lung cancer
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
head and neck cancer
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences, Vol 20, Iss 21, p 5452 (2019), International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....c9d9af8ade6ed8321b3bebf08e80d38e