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Neuroprotection by the α2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia
- Source :
- European Journal of Pharmacology. 372:31-36
- Publication Year :
- 1999
- Publisher :
- Elsevier BV, 1999.
-
Abstract
- The present study was undertaken to explore the possible neuroprotective effect of the selective alpha2-adrenoceptor agonist, dexmedetomidine in a rat model of focal cerebral ischemia. The effect of dexmedetomidine (9 microg kg(-1)) on infarct volume was assessed and compared to that of glutamate receptor antagonists cis-4(phosphonomethyl)-2-piperidine carboxylic acid (CGS-19755) (20 mg kg(-1)) or 2,3-dihydro-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) (50 mg kg(-1)). Dexmedetomidine decreased total ischemic volume by 40% in the cortex (P
- Subjects :
- Male
Agonist
medicine.drug_class
Ischemia
Arterial Occlusive Diseases
Pharmacology
Neuroprotection
chemistry.chemical_compound
Quinoxalines
medicine
Animals
Glutamate receptor antagonist
Rats, Wistar
Dexmedetomidine
Cerebral Cortex
business.industry
Body Weight
Imidazoles
Glutamate receptor
Cerebral Infarction
Cerebral Arteries
Medetomidine
medicine.disease
Corpus Striatum
Rats
Neuroprotective Agents
chemistry
Ischemic Attack, Transient
Pipecolic Acids
Anesthesia
NBQX
business
Adrenergic alpha-Agonists
Excitatory Amino Acid Antagonists
medicine.drug
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 372
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....c9d97824545611f2bc5cbe443333a57e