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Influence of Lymphatic Invasion on Locoregional Recurrence Following Mastectomy: Indication for Postmastectomy Radiotherapy for Breast Cancer Patients With One to Three Positive Nodes
- Source :
- International Journal of Radiation Oncology*Biology*Physics. 83:845-852
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- The indication for postmastectomy radiotherapy (PMRT) in breast cancer patients with one to three positive lymph nodes has been in discussion. The purpose of this study was to identify patient groups for whom PMRT may be indicated, focusing on varied locoregional recurrence rates depending on lymphatic invasion (ly) status.Retrospective analysis of 1,994 node-positive patients who had undergone mastectomy without postoperative radiotherapy between January 1990 and December 2000 at our hospital was performed. Patient groups for whom PMRT should be indicated were assessed using statistical tests based on the relationship between locoregional recurrence rate and ly status.Multivariate analysis showed that the ly status affected the locoregional recurrence rate to as great a degree as the number of positive lymph nodes (p0.001). Especially for patients with one to three positive nodes, extensive ly was a more significant factor than stage T3 in the TNM staging system for locoregional recurrence (p0.001 vs. p = 0.295).Among postmastectomy patients with one to three positive lymph nodes, patients with extensive ly seem to require local therapy regimens similar to those used for patients with four or more positive nodes and also seem to require consideration of the use of PMRT.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Multivariate analysis
Lymphovascular invasion
medicine.medical_treatment
Breast Neoplasms
Breast cancer
Internal medicine
medicine
Humans
Neoplasm Invasiveness
Radiology, Nuclear Medicine and imaging
Postoperative Period
Mastectomy
Neoplasm Staging
Retrospective Studies
Radiation
business.industry
Age Factors
Retrospective cohort study
Middle Aged
Postmastectomy radiation
medicine.disease
Tumor Burden
Axilla
medicine.anatomical_structure
Receptors, Estrogen
Lymphatic Metastasis
Multivariate Analysis
Female
Lymph Nodes
Lymph
Neoplasm Recurrence, Local
Receptors, Progesterone
business
Subjects
Details
- ISSN :
- 03603016
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- International Journal of Radiation Oncology*Biology*Physics
- Accession number :
- edsair.doi.dedup.....c9d7539fb4615b8df03f500a35258e34