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The Gender-Specific Association of DRD2 Polymorphism with Metabolic Syndrome in Patients with Schizophrenia
- Source :
- Genes, 13(8):1312. MDPI AG, Genes; Volume 13; Issue 8; Pages: 1312
- Publication Year :
- 2022
-
Abstract
- BACKGROUND: Metabolic syndrome is widespread in patients with schizophrenia receiving long-term antipsychotic therapy. Dopamine D2 receptors play an important role in mediating both the therapeutic actions of antipsychotics and their side effects. The present study examined the association of two polymorphisms of the DRD2 gene with metabolic syndrome in patients with schizophrenia.METHODS: We examined 517 patients from several regions of Siberia (Russia) with a clinical diagnosis of schizophrenia. Genotyping of two single nucleotide polymorphisms rs1799732 and rs4436578 of the dopamine D2 receptor gene (DRD2) was performed in a population of 471 patients. The results were analyzed using chi-square tests.RESULTS: Functional polymorphism rs1799732 of the DRD2 gene is associated with drug-induced metabolic syndrome in women with schizophrenia.CONCLUSIONS: Our results show that the DRD2 gene may be involved in the pathogenesis of metabolic disorders in patients with schizophrenia. Further analysis of possible genetic markers will allow for personalized treatment with minimal side effects and optimal efficacy. This which seems relevant in light of the recent focus on improving the quality of life and ensuring a high level of social adaptation of patients with schizophrenia.
- Subjects :
- Male
Metabolic Syndrome
Receptors, Dopamine D2
Polymorphism, Single Nucleotide/genetics
Receptors, Dopamine D2/genetics
Polymorphism, Single Nucleotide
Schizophrenia/drug therapy
Sex Factors
Dopamine D2/genetics
Receptors
Genetics
Schizophrenia
Quality of Life
Humans
schizophrenia
metabolic syndrome
dopamine D2 receptor
gene polymorphism
women
Female
Polymorphism
Antipsychotic Agents/adverse effects
Single Nucleotide/genetics
Genetics (clinical)
Metabolic Syndrome/genetics
Antipsychotic Agents
Subjects
Details
- Language :
- English
- ISSN :
- 20734425
- Database :
- OpenAIRE
- Journal :
- Genes, 13(8):1312. MDPI AG, Genes; Volume 13; Issue 8; Pages: 1312
- Accession number :
- edsair.doi.dedup.....c9cd6380be95eb5e0073efdae2828bc4