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Sleep quality and the treatment of intestinal microbiota imbalance in Chronic Fatigue Syndrome: A pilot study
- Source :
- Sleep Science, Sleep Science, Vol 8, Iss 3, Pp 124-133 (2015)
- Publisher :
- Brazilian Association of Sleep. Published by Elsevier B.V.
-
Abstract
- Chronic Fatigue Syndrome (CFS) is a multisystem illness, which may be associated with imbalances in gut microbiota. This study builds on recent evidence that sleep may be influenced by gut microbiota, by assessing whether changes to microbiota in a clinical population known to have both poor sleep and high rates of colonization with gram-positive faecal Streptococcus, can improve sleep. Twenty-one CFS participants completed a 22-day open label trial. Faecal microbiota analysis was performed at baseline and at the end of the trial. Participants were administered erythromycin 400mg b.d. for 6 days. Actigraphy and questionnaires were used to monitor sleep, symptoms and mood. Changes in patients who showed a clinically significant change in faecal Streptococcus after treatment (responders; defined as post-therapy distribution
- Subjects :
- Chronic Fatigue Syndrome
medicine.medical_specialty
HPA, hypothalamic-pituitary adrenal
lcsh:BF1-990
Population
Neuroscience (miscellaneous)
Medicine (miscellaneous)
lcsh:Consciousness. Cognition
Gut flora
SFI, sleep fragmentation index
CNS, central nervous system
Behavioral Neuroscience
Internal medicine
Lactobacillus
Full Length Article
Mood
Chronic fatigue syndrome
medicine
Psychiatry
education
TST, total sleep time
POMS, Profile of Mood States
education.field_of_study
biology
business.industry
Actigraphy
lcsh:BF309-499
biology.organism_classification
medicine.disease
Sleep in non-human animals
3. Good health
Clinical trial
lcsh:Psychology
FMA, faecal microbiota analysis
CFS, Chronic Fatigue Syndrome
Intestinal dysbiosis
MALDI-TOF MS, matrix assisted laser desorption ionization – time of flight mass spectrometry
WASO, wake after sleep onset
SOL, sleep onset latency
business
Sleep
Subjects
Details
- Language :
- English
- ISSN :
- 19840063
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Sleep Science
- Accession number :
- edsair.doi.dedup.....c9cd48289d1925caef7e5f40fc972d10
- Full Text :
- https://doi.org/10.1016/j.slsci.2015.10.001