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Asbestos: a hidden player behind the cholangiocarcinoma increase? Findings from a case–control analysis
- Source :
- Cancer Causes & Control
- Publisher :
- Springer Nature
-
Abstract
- PURPOSES: We conducted a case-control analysis to explore the association between occupational exposure to asbestos and cholangiocarcinoma (CC). METHODS: The study was based on historical data from 155 consecutive patients with CC [69 intrahepatic CC (ICC) and 86 extrahepatic CC (ECC)] referred to Sant'Orsola-Malpighi University Hospital between 2006 and 2010. The cases were individually matched by calendar period of birth, sex, and region of residence to historical hospital and population controls. Occupational exposure to asbestos was retrospectively assessed considering job titles obtained from work histories. Separate conditional logistic regression models were applied for ECC and ICC. Estimates were adjusted for smoking status and socioeconomic class. RESULTS: We matched 149 controls (median birth year: 1947; males: 56 %) to 41 cases of ICC (median birth year: 1946; males: 56 %) and 212 controls (median birth year: 1945; males: 48 %) to 59 cases of ECC (median birth year: 1945; males 51 %); 53 cases were not matched due to residence or birth year. We found an increased risk of ICC in workers exposed to asbestos (adjusted OR 4.81, 95 % CI 1.73-13.33); we also observed suggestive evidence that asbestos exposure might be associated with ECC (adjusted OR 2.09, 95 % CI 0.83-5.27). Sensitivity analysis restricted to patients from the Province of Bologna produced confirmatory figures. CONCLUSIONS: Our findings suggest that ICC could be associated with asbestos exposure; a chronic inflammatory pathway is hypothesized. Exposure to asbestos could be one of the determinants of the progressive rise in the incidence of ICC during the last 30 years.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Cancer Research
Socio-culturale
medicine.disease_cause
digestive system
Asbestos
Occupational medicine
Economica
Risk Factors
Internal medicine
ASBESTOS
medicine
Humans
neoplasms
Aged
Aged, 80 and over
Original Paper
business.industry
General surgery
Ambientale
Occupational exposure
Middle Aged
digestive system diseases
Case–control studies
OCCUPATIONAL MEDICINE
Bile Ducts, Intrahepatic
Bile Duct Neoplasms
Socioeconomic Factors
Case-Control Studies
Occupational diseases
Case control analysis
Female
cholangiocarcinoma
business
Subjects
Details
- Language :
- English
- ISSN :
- 09575243
- Volume :
- 24
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cancer Causes & Control
- Accession number :
- edsair.doi.dedup.....c9c3e301dd09e191786ea3e0096ff9dc
- Full Text :
- https://doi.org/10.1007/s10552-013-0167-3