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Massive Spread of OXA-48 Carbapenemase-Producing Enterobacteriaceae in the Environment of a Swiss Companion Animal Clinic
- Source :
- Antibiotics; Volume 11; Issue 2; Pages: 213, Schmitt, Kira; Biggel, Michael; Stephan, Roger; Willi, Barbara (2022). Massive Spread of OXA-48 Carbapenemase-Producing Enterobacteriaceae in the Environment of a Swiss Companion Animal Clinic. Antibiotics, 11(2) MDPI 10.3390/antibiotics11020213
- Publication Year :
- 2022
- Publisher :
- MDPI, 2022.
-
Abstract
- Background: Companion animal clinics contribute to the spread of antimicrobial resistant microorganisms (ARM) and outbreaks with ARM of public health concern have been described. Methods: As part of a project to assess infection prevention and control (IPC) standards in companion animal clinics in Switzerland, a total of 200 swabs from surfaces and 20 hand swabs from employees were collected during four days in a medium-sized clinic and analyzed for extended spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E), carbapenemase-producing Enterobacteriaceae (CPE), vancomycin-resistant enterococci (VRE), and methicillin-resistant staphylococci (MRS). Results: A total of 22 (11.0%) environmental specimen yielded CPE, 14 (7.0%) ESBL-E, and 7 (3.5%) MRS; MR Staphylococcus aureus were isolated from two (10.0%) hand swabs. The CPE isolates comprised Escherichia coli, Klebsiella pneumoniae, Enterobacter hormaechei, Citrobacter braakii, and Serratia marcescens. Whole genome sequencing revealed that all CPE carried closely related blaOXA-48 plasmids, suggesting a plasmidic spread within the clinic. The clinic exhibited major deficits in surface disinfection, hand hygiene infrastructure, and hand hygiene compliance. CPE were present in various areas, including those without patient contact. The study documented plasmidic dissemination of blaOXA-48 in a companion animal clinic with low IPC standards. This poses a worrisome threat to public health and highlights the need to foster IPC standards in veterinary clinics to prevent the spread of ARM into the community.
- Subjects :
- Microbiology (medical)
10253 Department of Small Animals
1303 Biochemistry
2404 Microbiology
610 Medicine & health
2725 Infectious Diseases
biochemical phenomena, metabolism, and nutrition
Toxicology and Pharmaceutics
Biochemistry
Microbiology
3000 General Pharmacology, Toxicology and Pharmaceutics
2726 Microbiology (medical)
Infectious Diseases
General Pharmacology
570 Life sciences
biology
2736 Pharmacology (medical)
Pharmacology (medical)
General Pharmacology, Toxicology and Pharmaceutics
CPE
CTX-M15
ESBL
IPC
hand hygiene
carbapenemase
OXA-48
IncL
plasmid
10082 Institute of Food Safety and Hygiene
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Antibiotics; Volume 11; Issue 2; Pages: 213, Schmitt, Kira; Biggel, Michael; Stephan, Roger; Willi, Barbara (2022). Massive Spread of OXA-48 Carbapenemase-Producing Enterobacteriaceae in the Environment of a Swiss Companion Animal Clinic. Antibiotics, 11(2) MDPI 10.3390/antibiotics11020213 <http://dx.doi.org/10.3390/antibiotics11020213>
- Accession number :
- edsair.doi.dedup.....c9c1952c0dff72f5d5b0f3fa3fb39ee0
- Full Text :
- https://doi.org/10.48350/166113