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Natural paratuberculosis infection in rabbits in Scotland
- Source :
- Journal of comparative pathology. 124(4)
- Publication Year :
- 2001
-
Abstract
- Natural paratuberculosis infection of rabbits ( Oryctolagus cuniculus ) was recently diagnosed in Scotland, and an investigation into the pathology of the disease in wild rabbits is reported in this paper. Evidence of Mycobacterium avium subsp. paratuberculosis ( M.a. paratuberculosis ) infection was detected in 22% of 110 rabbits; the organism was cultured from 17 of 110 rabbits, and histopathological lesions consistent with M.a. paratuberculosis infection were noted in 18 of 98 rabbits examined. No macroscopical lesions suggestive of M.a. paratuberculosis infection were observed. The histopathological lesions were either severe or mild. Severe lesions consisted of extensive macrophage granulomata and numerous giant cells, with many intracellular acid-fast bacteria in the small intestine. For the examination of formalin-fixed, paraffin wax-embedded tissues, neither immunohistochemistry nor the polymerase chain reaction was as sensitive a method of diagnosis as histopathology.
- Subjects :
- DNA, Bacterial
Pathology
medicine.medical_specialty
Paratuberculosis
Animals, Wild
Biology
Polymerase Chain Reaction
Pathology and Forensic Medicine
law.invention
law
Intestine, Small
medicine
Macrophage
Animals
Mesentery
Fluorescent Antibody Technique, Indirect
Polymerase chain reaction
Antigens, Bacterial
Granuloma
General Veterinary
medicine.disease
biology.organism_classification
Small intestine
Mycobacterium avium subsp. paratuberculosis
medicine.anatomical_structure
Scotland
Giant cell
Immunohistochemistry
Histopathology
Cattle
Lymph Nodes
Rabbits
Mycobacterium
Subjects
Details
- ISSN :
- 00219975
- Volume :
- 124
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of comparative pathology
- Accession number :
- edsair.doi.dedup.....c9bb346ee478b2ff7b2a77348f934fe1