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New Insights into Osteogenic and Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells and Their Potential Clinical Applications for Bone Regeneration in Pediatric Orthopaedics
- Source :
- Stem Cells International, Stem Cells International, Vol 2013 (2013)
- Publication Year :
- 2013
- Publisher :
- Hindawi Limited, 2013.
-
Abstract
- Human mesenchymal stem cells (hMSCs) are pluripotent adult stem cells capable of being differentiated into osteoblasts, adipocytes, and chondrocytes. The osteogenic differentiation of hMSCs is regulated either by systemic hormones or by local growth factors able to induce specific intracellular signal pathways that modify the expression and activity of several transcription factors. Runt-related transcription factor 2 (Runx2) and Wnt signaling-related molecules are the major factors critically involved in the osteogenic differentiation process by hMSCs, and SRY-related high-mobility-group (HMG) box transcription factor 9 (SOX9) is involved in the chondrogenic one. hMSCs have generated a great interest in the field of regenerative medicine, particularly in bone regeneration. In this paper, we focused our attention on the molecular mechanisms involved in osteogenic and chondrogenic differentiation of hMSC, and the potential clinical use of hMSCs in osteoarticular pediatric disease characterized by fracture nonunion and pseudarthrosis.
- Subjects :
- lcsh:Internal medicine
endocrine system
Pathology
medicine.medical_specialty
business.industry
Mesenchymal stem cell
Wnt signaling pathway
Review Article
Cell Biology
SOX9
equipment and supplies
Chondrogenesis
Regenerative medicine
Cell biology
RUNX2
medicine
lcsh:RC31-1245
business
Bone regeneration
Molecular Biology
Adult stem cell
Subjects
Details
- ISSN :
- 16879678 and 1687966X
- Volume :
- 2013
- Database :
- OpenAIRE
- Journal :
- Stem Cells International
- Accession number :
- edsair.doi.dedup.....c9b65a968644a409fffd94343b6e0710