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Cytotoxic bisbenzylisoquinoline alkaloids from the roots of Cyclea racemosa
- Source :
- Journal of natural products. 73(7)
- Publication Year :
- 2010
-
Abstract
- Six new bisbenzylisoquinoline alkaloids, racemosidines A-C (1-3) and racemosinines A-C (4-6), and four known compounds were isolated from the roots of Cyclea racemosa. Compound 1 is the first bisbenzylisoquinoline alkaloid reported that has diphenyl ether bridges at C-11/C-7' and C-8/C-12' and a benzyl-phenyl ether bridge at C-7/C-11'. Structures and absolute configurations of 1-6 were established by interpretation of spectroscopic data and confirmed by X-ray crystallographic analysis of representative compounds. Compounds 1-3 exhibited significant cytotoxicity against HCT-8 and BEL-7402 tumor cells, and compound 1 was also cytotoxic against A2780 tumor cells.
- Subjects :
- Stereochemistry
Chemical structure
Molecular Conformation
Pharmaceutical Science
Ether
Crystallography, X-Ray
Benzylisoquinolines
Plant Roots
Analytical Chemistry
chemistry.chemical_compound
Alkaloids
Drug Discovery
Humans
Menispermaceae
Medicinal plants
Cytotoxicity
Pharmacology
biology
Molecular Structure
Alkaloid
Organic Chemistry
Diphenyl ether
Cyclea
Biological activity
biology.organism_classification
Isoquinolines
Antineoplastic Agents, Phytogenic
Complementary and alternative medicine
chemistry
Molecular Medicine
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 15206025
- Volume :
- 73
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of natural products
- Accession number :
- edsair.doi.dedup.....c9b39cccf1ac28898a202d5cb0abcabf