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Plasma calprotectin in the emergency department: a potential clinical biomarker for patients with infectious diseases
- Source :
- Scandinavian journal of clinical and laboratory investigation. 81(7)
- Publication Year :
- 2021
-
Abstract
- Increased levels of plasma calprotectin are reported in patients with infectious diseases. However, the clinical usefulness of calprotectin as a biomarker to identify patients with infectious diseases in the emergency department (ED) setting has not been investigated. To study the ability of calprotectin to discriminate patients with acute infectious diseases and dyspnea from patients with other causes of acute dyspnea in the ED setting. Patients aged ≥18 years seeking ED during daytime on weekdays between March 2013 and July 2018, with acute dyspnea, were included. Participants (n = 1287) were triaged according to Medical Emergency Triage and Treatment System-Adult score (METTS-A) or Rapid Emergency Triage and Treatment System (RETTS), and blood samples were collected. The association between calprotectin and other markers of infectious diseases, i.e. biomarkers (CRP, leucocytes) and body temperature, was studied. The predictive value of calprotectin for the outcome of acute infection was evaluated with receiver operating characteristic (ROC) analysis. Univariate cross-sectional regression showed significant associations between calprotectin and leucocytes, CRP and body temperature. Patients with severe infections including pneumonia (n = 119) had significantly higher concentrations of calprotectin compared to patients with heart failure (n = 162) or chronic obstructive pulmonary disease (n = 183). When tested for the outcome of acute infection (n = 109), the area under the ROC curve (AUROC) was for CRP 0.83 and for calprotectin 0.78. Plasma calprotectin identifies infectious diseases in ED patients with acute dyspnea, and the clinical usefulness of Calprotectin in the ED has to be further studied.
- Subjects :
- Male
medicine.medical_specialty
Infectious Medicine
Clinical Biochemistry
communicable diseases
Infektionsmedicin
leukocyte L1 antigen complex (calprotectin)
Communicable Diseases
C-reactive protein
fluids and secretions
Risk Factors
Internal medicine
medicine
Leukocytes
Humans
Cardiac and Cardiovascular Systems
hospital
Aged
Aged, 80 and over
Kardiologi
biology
business.industry
General Medicine
Emergency department
Pneumonia
dyspnea
Middle Aged
medicine.disease
Triage
predictive value of tests
C-Reactive Protein
Predictive value of tests
Heart failure
biology.protein
Biomarker (medicine)
Female
Calprotectin
business
Emergency Service, Hospital
Leukocyte L1 Antigen Complex
Emergency service
Biomarkers
Subjects
Details
- ISSN :
- 15027686
- Volume :
- 81
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Scandinavian journal of clinical and laboratory investigation
- Accession number :
- edsair.doi.dedup.....c9a15c6eb3db2028555cbf3101ad20b7