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mPGES-1 knock-out mice are resistant to cancer-induced anorexia despite the absence of central mPGES-1 up-regulation in wild-type anorexic mice
- Source :
- Journal of Neuroimmunology, Journal of Neuroimmunology, Elsevier, 2008, 199 (1-2), pp.104-14. ⟨10.1016/j.jneuroim.2008.05.012⟩, Journal of Neuroimmunology, 2008, 199 (1-2), pp.104-14. ⟨10.1016/j.jneuroim.2008.05.012⟩
- Publication Year :
- 2008
- Publisher :
- HAL CCSD, 2008.
-
Abstract
- International audience; Anorexia-cachexia syndrome is a very common symptom observed in individuals affected by chronic inflammatory diseases. The present study was designed to address the possible involvement of the inducible microsomal prostaglandin E synthase-1 (mPGES-1) in the hypopaghia observed during these pathological states. To this end, we used a model of cancer-induced anorexia and we report here that despite the absence of up-regulation of the mPGES-1 enzyme within the brain during anorexia-cachexia syndrome, mPGES-1 knock-out mice exhibit resistance to tumor-induced anorexia and maintain their body mass.
- Subjects :
- Male
MESH: Inflammation
Cachexia
medicine.medical_treatment
MESH: Mice, Knockout
Mice
0302 clinical medicine
Neoplasms
MESH: Reverse Transcriptase Polymerase Chain Reaction
MESH: Up-Regulation
Immunology and Allergy
MESH: Animals
MESH: Neoplasms
Prostaglandin-E Synthases
Mice, Knockout
0303 health sciences
MESH: Cytokines
Reverse Transcriptase Polymerase Chain Reaction
digestive, oral, and skin physiology
Brain
3. Good health
Anorexia
Up-Regulation
Intramolecular Oxidoreductases
Neurology
Hypothalamus
Knockout mouse
Cytokines
lipids (amino acids, peptides, and proteins)
medicine.symptom
Prostaglandin E
musculoskeletal diseases
medicine.medical_specialty
Immunology
Blotting, Western
Biology
03 medical and health sciences
MESH: Brain
Downregulation and upregulation
Internal medicine
medicine
Animals
MESH: Blotting, Western
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
Pathological
MESH: Mice
030304 developmental biology
Inflammation
Wild type
Cancer
medicine.disease
MESH: Intramolecular Oxidoreductases
MESH: Male
Endocrinology
MESH: Cachexia
MESH: Anorexia
Neurology (clinical)
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 01655728
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology, Journal of Neuroimmunology, Elsevier, 2008, 199 (1-2), pp.104-14. ⟨10.1016/j.jneuroim.2008.05.012⟩, Journal of Neuroimmunology, 2008, 199 (1-2), pp.104-14. ⟨10.1016/j.jneuroim.2008.05.012⟩
- Accession number :
- edsair.doi.dedup.....c99b334d937c8a78fcdcd554775bf3cb