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BETA.1 and .BETA.2 Adrenoceptor Ligand and mRNA Expression in Dilated Cardiomyopathy
- Source :
- Biological and Pharmaceutical Bulletin. 18:1430-1434
- Publication Year :
- 1995
- Publisher :
- Pharmaceutical Society of Japan, 1995.
-
Abstract
- beta 1 and beta 2 adrenoceptor ligand activity has been shown to be down-regulated in failing myocardium. It is the aim of this study to test the hypothesis that also mRNA levels are down-regulated in dilated cardiomyopathy. beta 1 and beta 2 adrenoceptor ligand activities and mRNA expressions were analyzed in left ventricular biopsies from six organ donor hearts, in papillary muscles from seven patients operated on for mitral regurgitation, and in six explanted hearts as the result of dilated cardiomyophathy. mRNA levels were determined by solution hybridization. beta 1 ligand activity was decreased in the cases of mitral regurgitation (p0.01) and dilated cardiomyopathy (p0.001). beta 2 ligand activity did not differ between the three groups. mRNA expression was depressed in mitral regurgitation regarding both beta 1 (p0.001) and beta 2 (p0.01), while no differences were observed in dilated cardiomyopathy as compared to the donor hearts. The regulation of beta 1 and beta 2 adrenoceptor ligand activity and mRNA expression appears to follow a specific pattern in dilated cardiomyopathy. The specific down-regulation of beta 1 ligand activity seems to occur at a posttranslational level.
- Subjects :
- Adult
Cardiomyopathy, Dilated
medicine.medical_specialty
Adolescent
Adrenergic receptor
Heart disease
Adrenergic beta-Antagonists
Molecular Sequence Data
Down-Regulation
Pharmaceutical Science
In Vitro Techniques
Ligands
Internal medicine
medicine
Humans
RNA, Messenger
In Situ Hybridization
Aged
Pharmacology
Messenger RNA
Mitral regurgitation
Mitral Valve Prolapse
Base Sequence
business.industry
Myocardium
Hypertrophic cardiomyopathy
Dilated cardiomyopathy
General Medicine
Middle Aged
Papillary Muscles
Ligand (biochemistry)
medicine.disease
Endocrinology
Adipose Tissue
Liver
Solution hybridization
Receptors, Adrenergic, beta-2
Receptors, Adrenergic, beta-1
business
Subjects
Details
- ISSN :
- 13475215 and 09186158
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Biological and Pharmaceutical Bulletin
- Accession number :
- edsair.doi.dedup.....c998569ec7b7123c0474061cc623dd45