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Obesity-Induced Peritoneal Dissemination of Ovarian Cancer and Dominant Recruitment of Macrophages in Ascites
- Source :
- Immune Network
- Publication Year :
- 2018
- Publisher :
- The Korean Association of Immunologists, 2018.
-
Abstract
- One-fifth of cancer deaths are associated with obesity. Because the molecular mechanisms by which obesity affects the progression of ovarian cancer (OC) are poorly understood, we investigated if obesity could promote the progression of OC cells using the postmenopausal ob/ob mouse model and peritoneal dissemination of mouse ID8 OC cells. Compared to lean mice, obese mice had earlier OC occurrence, greater metastasis throughout the peritoneal cavity, a trend toward shorter survival, and higher circulating glucose and proinflammatory chemokine CXCL1 levels. Ascites in obese mice had higher levels of macrophages (Mφ) and chemokines including CCL2, CXCL12, CXCL13, G-CSF and M-CSF. Omental tumor tissues in obese mice had more adipocytes than lean mice. Our data suggest that obesity may accelerate the peritoneal dissemination of OC through higher production of pro-inflammatory chemokines and Mφ recruitment.
- Subjects :
- 0301 basic medicine
Chemokine
medicine.medical_specialty
Immunology
CCL2
Brief Communication
Metastasis
Proinflammatory cytokine
03 medical and health sciences
Peritoneal cavity
0302 clinical medicine
Ovarian cancer
Internal medicine
Immunology and Allergy
Medicine
Obesity
CXCL13
biology
business.industry
Macrophages
Cancer
Ascites
medicine.disease
3. Good health
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
Endocrinology
030220 oncology & carcinogenesis
biology.protein
Chemokines
business
Subjects
Details
- Language :
- English
- ISSN :
- 20926685 and 15982629
- Volume :
- 18
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Immune Network
- Accession number :
- edsair.doi.dedup.....c98c958663a39c8bdb08ccdb68186b71