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Non-ulcerogenic pyrazolyl 2-hydroxychalcones and pyrazolylpyrazolines derived from naturally existing furochromone (khellin): semi-synthesis, docking study and anti-inflammatory activity
- Source :
- Natural product research. 36(10)
- Publication Year :
- 2021
-
Abstract
- Novel pyrazolyl 2-hydroxychalcone derivatives 3a–e and pyrazolylpyrazoline derivatives 4a–e and 5a–j derived from the naturally existing furochromone (Khellin) were synthesized and evaluated for th...
- Subjects :
- Khellin
Diclofenac
Stereochemistry
medicine.drug_class
Anti-Inflammatory Agents
Plant Science
Pyrazole
01 natural sciences
Biochemistry
Anti-inflammatory
Analytical Chemistry
chemistry.chemical_compound
Structure-Activity Relationship
Docking (dog)
medicine
Animals
Edema
Cyclooxygenase 2 Inhibitors
Molecular Structure
010405 organic chemistry
Chemistry
Organic Chemistry
Anti-Inflammatory Agents, Non-Steroidal
0104 chemical sciences
Rats
Molecular Docking Simulation
010404 medicinal & biomolecular chemistry
Celecoxib
Cyclooxygenase 2
Subjects
Details
- ISSN :
- 14786427
- Volume :
- 36
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Natural product research
- Accession number :
- edsair.doi.dedup.....c988fed06a0da0af4fdeb2fc638271ce