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Paradoxical functions of long noncoding RNAs in modulating STAT3 signaling pathway in hepatocellular carcinoma
- Source :
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1876:188574
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Hepatocellular carcinoma (HCC) is one of the lethal and leading types of cancer threatening the globe with a high mortality rate. STAT3 is an oncogenic transcription factor that is aberrantly activated in several human malignancies including HCC. Many STAT3-driven genes control cell proliferation and survival, apoptotic resistance, cell cycle progression, metastasis, and chemotherapeutic resistance. STAT3 signaling is regulated by endogenous modulators such as protein tyrosine phosphatase (PTP), suppressor of cytokine signaling (SOCS), protein inhibitor of activated STAT (PIAS), and various long noncoding RNAs (lncRNAs). Interestingly, lncRNAs have been reported to exhibit oncogenic and tumor suppressor functions, and these effects are mediated through diverse molecular mechanisms including sponging of microRNAs (miRs), transcription activation/inhibition, and epigenetic modifications. In this article, we have discussed the possible role of STAT3 signaling in hepatocarcinogenesis and various mechanisms by which lncRNAs impart their oncogenic or tumor suppressive action by modulating the STAT3 pathway in HCC.
- Subjects :
- STAT3 Transcription Factor
0301 basic medicine
Cancer Research
Carcinoma, Hepatocellular
Protein tyrosine phosphatase
Stat3 Signaling Pathway
03 medical and health sciences
0302 clinical medicine
microRNA
Genetics
Animals
Humans
Genes, Tumor Suppressor
Protein inhibitor of activated STAT
Epigenetics
STAT3
Transcription factor
biology
Competing endogenous RNA
Liver Neoplasms
Oncogenes
Gene Expression Regulation, Neoplastic
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
biology.protein
Cancer research
RNA, Long Noncoding
Signal Transduction
Subjects
Details
- ISSN :
- 0304419X
- Volume :
- 1876
- Database :
- OpenAIRE
- Journal :
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Accession number :
- edsair.doi.dedup.....c967e2f86dccb1461a65c47133d20fca