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Risk for Mortality From Causes Other Than Pancreatic Cancer in Patients With Intraductal Papillary Mucinous Neoplasm of the Pancreas
- Source :
- Pancreas. 42:687-691
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- The long-term prognosis in patients with intraductal papillary mucinous neoplasm (IPMN) has not been determined. The aim of this study was to elucidate the risk for nonpancreatic cancer-specific mortality in patients with IPMN.Seven hundred ninety-three patients with IPMN who were followed up more than 1 year were included in this study. Fine and Gray competing risk regression was used to assess the risk for mortality unrelated to pancreatic cancer. A comorbidity score at diagnosis was assigned using the Adult Comorbidity Evaluation 27.After a median follow-up of 50 months, a high comorbidity score and age at diagnosis were significantly associated with a risk for mortality unrelated to pancreatic cancer. Adjusted hazards ratio and 95% confidence interval of each comorbidity burden were as follows: none, 1; mild, 2.68 (0.76-9.45; P = 0.124); moderate, 10.9 (3.19-37.1; P0.001); and severe, 32.0 (9.41-108.8; P0.001). Comorbidity burden did not affect the risk for pancreatic cancer-specific mortality.Comorbidity and age at diagnosis was significantly related to mortality unrelated to pancreatic cancer in patients with IPMN. For patients at high risk for nonpancreatic cancer mortality, a follow-up management may be more reasonable than surgery.
- Subjects :
- Male
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Comorbidity
Gastroenterology
Endocrinology
Japan
Risk Factors
Cause of Death
Internal medicine
Pancreatic cancer
Internal Medicine
medicine
Carcinoma
Humans
In patient
Aged
Cause of death
Hepatology
Intraductal papillary mucinous neoplasm
business.industry
Middle Aged
Prognosis
medicine.disease
Adenocarcinoma, Mucinous
Carcinoma, Papillary
Pancreatic Neoplasms
medicine.anatomical_structure
Adenocarcinoma
Female
Pancreas
business
Carcinoma, Pancreatic Ductal
Subjects
Details
- ISSN :
- 08853177
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.doi.dedup.....c95f2130abea215ed72bdab4a61419d3